Effect of the Modification of p24 Peptide Antigen on Dendritic Cell Uptake and T Cell Activation.

Background: Vacc-4x is a candidate therapeutic vaccine consisting of 4 modified peptides based on conserved regions of HIV-1 p24Gag. Vacc4x has been shown to induce long term cellular immunity in immunized infected individuals resulting a reduction in viral load on treatment interruption.

Objective: Vacc-4x peptides are modified.