Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment.

Eyelid margin basal cell carcinoma managed with full-thickness en-face frozen section histopathology.

Purpose: To determine the tumor control rate of basal cell carcinoma (BCC) of the eyelid margin managed by full-thickness eyelid resection with en-face frozen section-controlled margins and primary reconstruction of the defect.

Methods: This is a retrospective, consecutive, noncomparative, longitudinal interventional case series from a single institution. A review of medical records of all patients with BCC involving the eyelid margin treated by full-thickness en-face frozen section histopathology between June 1997 and June 2011 was conducted.

Vismodegib for periocular and orbital basal cell carcinoma.

Importance: Basal cell carcinoma (BCC) represents 90% of malignant eyelid tumors and is locally invasive and destructive, if left untreated.

Objective: To assess the feasibility of using vismodegib for periocular and orbital BCC based on its efficacy and tolerability.

Design, Setting, And Participants: In this prospective observational case series, consecutive patients with periocular or orbital BCC who met criteria for treatment with vismodegib were recruited prospectively during an 8-month period from February through September 2012 from 2 academic hospitals.

A new Cylindromatosis (CYLD) gene mutation in a case of Brooke-Spiegler syndrome masquerading as basal cell carcinoma of the eyelids.

A 70-year-old woman sought treatment for confluent flesh-colored papules on all 4 eyelids. Sixteen family members were reported to have similar lesions involving the face and scalp. Initial histopathologic examination of the lesions was interpreted as basal cell carcinoma, but on further review, the lesions were deemed to be consistent with trichoepitheliomas as seen in Brooke-Spiegler syndrome.

Silicone intubation for the treatment of epiphora in adults with presumed functional nasolacrimal duct obstruction.

Purpose: To evaluate the long-term efficacy of silicone intubation in adults with presumed functional nasolacrimal duct obstruction.

Methods: This retrospective cohort study reviewed adults with unilateral or bilateral epiphora and presumed functional nasolacrimal duct obstruction treated with silicone intubation and followed for signs of treatment failure (defined as persistent epiphora or need for a secondary procedure). Median time to event (failure) after silicone intubation was calculated using Kaplan-Meier survival analysis.

Human immunodeficiency virus-associated blepharoptosis.

Purpose: To better characterize an unusual blepharoptosis observed in HIV-positive patients and to evaluate histopathology.

Methods: This retrospective case series evaluated patients with HIV/AIDS and blepharoptosis with reduced levator excursion. Exclusion criteria included patients with identifiable causes of ptosis (e.

Developmental anatomy of the nasolacrimal duct: implications for congenital obstruction.

Objective: To measure the height, anteroposterior, and transverse diameters of the nasolacrimal duct (NLD) in normal children between 2 weeks and 34 months of age and to compare the development of the NLD with the maxilla.

Design: Retrospective case series.

Participants: Thirty-eight children with no history of NLD abnormalities who underwent prior axial computed tomography (CT) facial scans of 0.

Atypical canaliculitis.

A 34-year-old immunocompetent woman sought treatment for a 6-week history of right inferior medial canthal swelling and discharge consistent with canaliculitis. Symptoms persisted after conservative medical therapy. After canaliculotomy and removal of a dacryolith, the patient experienced resolution of signs and symptoms.

Floppy eyelid syndrome.

In this review, we define characteristics of floppy eyelid syndrome, as well as related syndromes, such as lax eyelid syndrome. Presenting symptoms, ocular signs, and important clinical examination techniques are described, and associated ocular and systemic conditions, as well as corresponding pathophysiology are discussed. Significant new histopathologic findings in floppy eyelid syndrome and recent surgical developments are summarized.