Publications by authors named "Evdokiya E Knyazhanskaya"
Introduction: Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long-term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).
Methods: Mayo Clinic Cohort Study of Oophorectomy and Aging-2 participants were divided into early PBO (< 46 years; n = 61), and late PBO (46-49 years; n = 51) groups and were compared to referent women who did not undergo PBO (n = 119).
Article Synopsis
- Exposure to repetitive head impacts (RHI) correlates with chronic traumatic encephalopathy (CTE), which can only be diagnosed after death; the study explores the presence of a cavum septum pellucidum (CSP) in living former football players to understand its relation to RHI and potential CTE.
- The research involved 175 former players, both college and professional, and compared their CSP measurements to a control group without RHI exposure, assessing associations with cumulative head impact and traumatic encephalopathy syndrome (TES).
- Results indicated that former players had significantly higher CSP presence and ratio compared to controls, with professional players exhibiting an even greater ratio; however, there was no notable link between CSP and TES or provisional
Article Synopsis
- * A study evaluated brain structures using MRI in 170 former football players and 54 controls, assessing regions associated with CTE pathology, revealing significant reductions in cortical thickness and volume in players compared to controls.
- * Former professional players showed more pronounced brain changes than former college players, specifically in areas like the hippocampus and amygdala, indicating that exposure to head impacts has lasting effects on brain structure.
Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine whether cortical thickness (CTh) heterogeneity in schizophrenia relates to interregional variation in distinct neural cell types, as inferred from established gene expression data and person-specific genomic variation. This study comprised 1849 participants in total, including a discovery (140 cases and 1267 controls) and a validation cohort (335 cases and 185 controls).
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