Hyponatraemia: A strong predictor of mortality in adults with congenital heart disease.

Aims: We studied the prevalence of hyponatraemia and its prognostic implications in a large population of adult patients with congenital heart disease (ACHD).

Methods And Results: A total of 1004 ACHD patients were retrospectively entered in this study (mean age 36.2 +/- 14.

Effect of pregnancy on clinical status and ventricular function in women with heart disease.

Background: Pregnant women with heart disease (HD) are at an increased risk for maternal and neonatal adverse events. However, the effect of pregnancy on clinical status and ventricular function in women with HD has not been examined in a controlled study.

Methods And Results: Ninety-three women with HD were studied longitudinally.

Prevalence, predictors, and prognostic value of renal dysfunction in adults with congenital heart disease.

Background: Renal insufficiency in patients with ischemic heart disease and acquired heart failure is associated with higher mortality and morbidity. We studied the prevalence of renal dysfunction in adult patients with congenital heart disease (ACHD) and its relation to outcome.

Methods And Results: A total of 1102 adult patients with congenital heart disease (age 36.

Long-term safety, tolerability and efficacy of bosentan in adults with pulmonary arterial hypertension associated with congenital heart disease.

Objective: To examine long-term safety and efficacy of bosentan--an oral dual endothelin receptor antagonist--in patients with pulmonary hypertension associated with congenital heart disease or Eisenmenger's syndrome.

Design: Retrospective study.

Setting: Tertiary cardiology referral centre.