Publications by authors named "Evans Berreondo Giron"
J Allergy Clin Immunol
August 2021
Article Synopsis
- Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma and nasal polyposis, and treatment with anti-IL-5 therapy, such as mepolizumab, shows clinical benefits beyond just reducing eosinophils.
- In a study of 18 AERD patients on mepolizumab, significant reductions in peripheral eosinophils and basophils, as well as lower levels of inflammatory eicosanoids, were observed compared to matched subjects not on the treatment.
- The treatment also led to changes in nasal epithelial cell gene expression related to tight junctions and cilium organization, indicating a broader impact of IL-5 inhibition on respiratory inflammation in AER
