Publications by authors named "Evangeline Pearson"
Article Synopsis
- * A study was conducted using mass spectrometry to analyze the differences in metabolome (metabolism) and proteome (proteins) between healthy left and right ventricles, revealing significant metabolic changes.
- * In advanced heart conditions like dilated and ischemic cardiomyopathy, the distinct metabolic pathways between the ventricles become less pronounced, but the left ventricle shows more adverse changes related to heart failure.
Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide. We perform unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, compared to age-, gender-, and BMI-matched, histopathologically normal, donor controls.
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