Publications by authors named "Evangeline Millicent Rodrigues"
Article Synopsis
- * A study of 257 individuals from 71 families found that approximately 20% of gene mutation carriers developed aHUS, indicating low penetrance, especially among siblings (7.47 events per 1000 person-years) and offspring (6.29 events per 1000 person-years).
- * The findings suggest that the disease risk is significantly lower than previously thought and varies by family relationship, emphasizing the need for careful consideration of genetic variant classifications over time.
Rationale And Objective: Patients with atypical hemolytic uremic syndrome (aHUS) have long been considered ineligible for kidney transplantation (KTx) in several centers due to the high risk of disease recurrence, graft loss and life-threatening complications. The availability of Eculizumab (ECU) has now overcome this problem. However, the best approach towards timing, maintenance schedule, the possibility of discontinuation and patient monitoring has not yet been clearly established.
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