Study of Subcutaneous Pressure in Lower Limb Cellulitis and its Correlation With Surgical Intervention.

Introduction Cellulitis is a prevalent bacterial skin infection, particularly affecting the lower limbs and often necessitating clinical intervention due to its considerable incidence rate. Factors like venous insufficiency, lymphedema, and recurring episodes increase the risk of relapse, complicating treatment strategies. Although antibiotics and limb elevation are standard care, severe cases may require surgical intervention.

Imaging Diagnosis of a Lumbar Hernia: A Rare and Challenging Presentation.

Lumbar hernias, a rare form of abdominal wall hernia, typically present with subtle, gradually enlarging masses in the lumbar region, often overlooked due to their rarity. This case report details a 38-year-old male farmer who experienced a 10-month history of a slowly enlarging, non-tender swelling in the left loin area, which became more prominent during the Valsalva maneuver. Despite having no significant medical history or prior trauma, a CT scan revealed a 2 cm defect in the superior lumbar triangle, with herniation of perinephric fat, confirming the diagnosis of a superior lumbar hernia.

Comparative Evaluation of USG-Guided Single Tissue Marker Versus Multiple Tissue Marker Placements in Breast Malignancy Patients Undergoing Neoadjuvant Chemotherapy for Tumor Localization.

Background Breast cancer remains one of the most common malignancies affecting women globally, contributing significantly to the disease burden. The advent of neoadjuvant chemotherapy (NAC) has revolutionized the treatment for locally advanced breast cancer, allowing tumors to be downstaged and making breast-conserving surgery (BCS) feasible. Accurate localization of the tumor bed post-NAC is crucial for successful surgical removal of residual disease.

A Study Assessing the Role of Renal Grayscale Ultrasonography and Flowmetry in Correlation With Renal Function Tests Across Various Renal Diseases.

Background Renal insufficiency, a critical concern in native and transplant kidneys, necessitates effective screening modalities for evaluation and management. Grayscale sonography has been a cornerstone in renal diagnostics, providing basic anatomical insights such as renal length, cortical thickness, and collecting system dilatation. Despite technological advancements, its impact on the differential diagnosis or management of renal disease remains limited, often showing normal findings in the presence of severe renal dysfunction.

Characterization and genome-informatic analysis of a novel lytic mendocina phage vB_PmeS_STP12 suitable for phage therapy pseudomonas or biocontrol.

Background: A novel lytic bacteriophage (phage) was isolated with Pseudomonas mendocina strain STP12 (P. mendocina) from the untreated site of Sewage Treatment Plant of Lovely Professional University, India. P.

Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics.

Bacteriophages (phages) are viruses that mainly infect bacteria and are ubiquitously distributed in nature, especially to their host. Phage engineering involves nucleic acids manipulation of phage genome for antimicrobial activity directed against pathogens through the applications of molecular biology techniques such as synthetic biology methods, homologous recombination, CRISPY-BRED and CRISPY-BRIP recombineering, rebooting phage-based engineering, and targeted nucleases including CRISPR/Cas9, zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). Management of bacteria is widely achieved using antibiotics whose mechanism of action has been shown to target both the genetic dogma and the metabolism of pathogens.