Monofunctional platinum complexes offer a promising alternative to cisplatin in cancer chemotherapy, showing a unique mechanism of action. Their ability to induce minor helix distortions effectively inhibits DNA transcription. In our study, we synthesized and characterized three monofunctional Pt(II) complexes with the general formula [Pt(en)(L)Cl]NO, where en = ethylenediamine, and L = pyridine (py), 2-methylpyridine (2-mepy), and 2-phenylpyridine (2-phpy).
View Article and Find Full Text PDFExtra virgin olive oil (EVOO) is recognized for its numerous health benefits, attributed to its rich phenolic components. NMR has emerged as a prevalent technique for precisely identifying these compounds. Among Mediterranean countries, Greece stands as the third-largest producer of olives, with the Epirus region notably advancing in olive cultivation, contributing significantly to the dynamic growth of the region.
View Article and Find Full Text PDFTwo novel sizable multicharged cationic complexes, of the formulae [(--[12]CPP)[Ru(--Cp)]]Χ and [(--[11]CPP)[Ru(--Cp)]]Χ, CPP = cycloparaphenylene, Cp = cyclopentadienyl, X = [PF], (), () and [Cl], (), (), were synthesized and characterized using NMR techniques, high-resolution mass spectrometry, and elemental analyses. Complexes () and () were stable in acetone and acetonitrile solutions over 48 h. In contrast, the water-soluble () and () begin to decompose in aqueous media after 1 h, due to the [Cl] tendency for nucleophilic attack on ruthenium of the {Ru(--Cp)} units.
View Article and Find Full Text PDFNovel full-sandwich (-Cp)-Ru-paraphenylene complexes with the general formula [(-Cp)Ru(-L)](PF) where n = 1-3 and L = biphenyl, -terphenyl and -quaterphenyl, were synthesized and characterized by means of spectroscopic and analytical techniques. The structures of the complexes [(-Cp)Ru(-biphenyl)](PF) (), [(-Cp)Ru(-terphenyl)](PF) () and [(-Cp)Ru(-terphenyl)](PF) () was determined by X-ray single crystal methods. The interaction of the complexes [(-Cp)Ru(-quaterphenyl)]Cl, ()Cl, and [(-Cp)Ru(-quaterphenyl)]Cl, ()Cl, with the DNA duplex d(5'-CGCGAATTCGCG-3') was studied using NMR techniques.
View Article and Find Full Text PDF