Phosphonylation Controls the Protein Corona of Multifunctional Polyglycerol-Modified Nanocarriers.

Nanocarriers are a platform for modern drug delivery. In contact with blood, proteins adsorb to nanocarriers, altering their behavior in vivo. To reduce unspecific protein adsorption and unspecific cellular uptake, nanocarriers are modified with hydrophilic polymers like poly(ethylene glycol) (PEG).

Reactions and Polymerizations at the Liquid-Liquid Interface.

Reactions and polymerizations at the interface of two immiscible liquids are reviewed. The confinement of two reactants at the interface to form a new product can be advantageous in terms of improved reaction kinetics, higher yields, and selectivity. The presence of the liquid-liquid interface can accelerate the reaction, or a phase-transfer catalyst is employed to draw the reaction in one phase of choice.

A molecular "screw-clamp": accelerating click reactions in miniemulsions.

The interface as a "screw clamp": the copper-free 1,3-dipolar azide-alkyne cycloaddition at the interface of nanodroplets in miniemulsions was studied in detail by NMR spectroscopic methods. The reaction at the oil-water interface proved to exhibit higher rate constants, increased molecular weights and high regioregularity compared to the reaction in solution.

Paclitaxel-loaded polyphosphate nanoparticles: a potential strategy for bone cancer treatment.

While it has been shown that phosphates can target molecules and nanocarriers to bone we herein demonstrate the preparation of polyphosphate nanoparticles loaded with paclitaxel using a simple miniemulsion/solvent-evaporation technique as a model for chemotherapeutic delivery. Polyphosphates exhibit much higher structural versatility, relying on the pentavalence of the phosphorus center compared to conventional polyesters. This versatility allows for the development of new degradable polymeric carriers with inherent bone adhesion ability by the interaction of the nanoparticles with a calcium phosphate material used for bone regeneration.