Publications by authors named "Evander de J Oliveira Batista"
Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms.
Front Cell Infect Microbiol
February 2025
Cerebral malaria is the most severe and lethal complication caused by infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting children under the age of five. Various hypotheses have been proposed to explain the neurological syndrome associated to cerebral malaria condition, including vascular occlusion and sequestration, cytokine storm or inflammatory response, or a combination of these mechanisms and despite extensive research and a growing range of scientific information, the precise pathophysiological mechanism remains poorly understood. In this sense, this review aims to explore the neurological impairment in cerebral malaria and elucidate novel mechanisms to explain the severity of this disease.
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- Acute stress significantly contributes to the onset of anxiety disorders, and zebrafish are commonly used to study the brain's response to stress and anxiety.
- The research focused on how acute restraint stress affects cell activation in the telencephalon of adult zebrafish, revealing reduced c-fos protein expression and lower GABA release following stress.
- The findings suggest that decreased GABA levels lead to less activation of GABAA receptors, resulting in heightened anxiety-like behavior, and indicate zebrafish may be useful for testing anxiolytic drugs targeting the GABAergic system.