"Someday, I'll be an ancestor:" Understanding indigenous intergenerational connectedness through qualitative research to inform measure development.

Intergenerational connectedness broadly encompasses relations among humans, lands, and all living and spiritual beings, and functions as an important part of Indigenous well-being. Many public health campaigns and interventions aim to promote connectedness to support holistic wellness and reduce health inequities. Currently, however, there are no measurement tools to assess intergenerational connectedness to support culturally grounded research and program evaluation.

Differential Insular Cortex Activation During Reward Anticipation in Major Depressive Disorder with and without Anxiety.

Background: Anticipation involves preparatory resource allocation to optimize upcoming responses, linked to insular cortex function. Although major depressive disorder (MDD) shows impairments in anticipatory processing and blunted insula activation, it is unclear whether this pattern holds across MDD with and without comorbid anxiety disorders (MDD+ANX). The Monetary Incentive Delay task (MID), combined with magnetic resonance imaging (MRI)-guided electroencephalogram (EEG) source localization, offers a robust approach to study anticipatory mechanisms in MDD subtypes.

Social support, spirituality, and executive functions: An event-related potential (ERP) study of neural mechanisms of cultural protective factors in American Indians (AIs).

A resilience-based approach in American Indian (AI) communities focuses on inherent sociocultural assets that may act as protective resilience buffers linked to mitigated mental health risks (e.g., deep-rooted spiritual, robust social support networks).

Utilizing Theoretical Domains Framework to Determine Barriers to Evidence-Based Recommendations in Non-Valvular Atrial Fibrillation.

Background: Implementation of evidence-based guidelines in patient care is inefficient. Only 14% of new research are routinely adopted into clinical practice. The atrial fibrillation (AF) practice guidelines recommend anticoagulation in men with a CHADS-VASc score greater than or equal to 2 and in women with a CHADS-VASc score greater than or equal to 3.

Anticipatory processing increases attentional biases to disgust faces in socially anxious individuals: Evidence from the N2pc and CDA.

Attentional biases to socially threatening facial expressions (anger, disgust) have been repeatedly observed in socially anxious individuals. These biases are thought to arise, in part, because anticipatory processing of social situations increases the salience of negative social cues. Additionally, self-focused attention on somatic symptoms of anxiety (e.

Increased Insular Functional Connectivity During Repetitive Negative Thinking in Major Depression and Healthy Volunteers.

Background: Repetitive negative thinking (RNT) in major depressive disorder (MDD) involves persistent focus on negative self-related experiences. Resting-state fMRI shows that the functional connectivity (FC) between the insula and the superior temporal sulcus is critical to RNT intensity. This study examines how insular FC patterns differ between resting-state and RNT-induction in MDD and healthy participants (HC).

Emerging Medical Technologies and Their Use in Bionic Repair and Human Augmentation.

As both the proportion of older people and the length of life increases globally, a rise in age-related degenerative diseases, disability, and prolonged dependency is projected. However, more sophisticated biomedical materials, as well as an improved understanding of human disease, is forecast to revolutionize the diagnosis and treatment of conditions ranging from osteoarthritis to Alzheimer's disease as well as impact disease prevention. Another, albeit quieter, revolution is also taking place within society: human augmentation.

Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration.

The field of hybrid engineered living materials seeks to pair living organisms with synthetic materials to generate biocomposite materials with augmented function since living systems can provide highly-programmable and complex behavior. Engineered living materials have typically been fabricated using techniques in benign aqueous environments, limiting their application. In this work, biocomposite fabrication is demonstrated in which spores from polymer-degrading bacteria are incorporated into a thermoplastic polyurethane using high-temperature melt extrusion.

A Biologically Degradable and BioseniaticTM Feedstock for the High-Quality 3D Printing of Anatomical Models.

A Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) -based filament was evaluated as an alternative feedstock for Fused Deposition Modeling (FDM) of instructional and clinical medical specimens. PHBHHx-based prints of domestic cat vertebrae, skull bone, and an aortic arch cast were found comparable to conventional materials. PHBHHx-based filament and extrudate samples were evaluated for biological degradability, to meet the BioseniaticTM standard, defined by the University of Georgia New Materials Institute.

Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation.

Hyperarousal symptoms in generalized anxiety disorder (GAD) are often incongruent with the observed physiological state, suggesting that abnormal processing of interoceptive signals is a characteristic feature of the disorder. To examine the neural mechanisms underlying interoceptive dysfunction in GAD, we evaluated whether adrenergic modulation of cardiovascular signaling differentially affects the heartbeat-evoked potential (HEP), an electrophysiological marker of cardiac interoception, during concurrent electroencephalogram and functional magnetic resonance imaging (EEG-fMRI) scanning. Intravenous infusions of the peripheral adrenergic agonist isoproterenol (0.

Cognitive control as a potential neural mechanism of protective role of spirituality in anxiety disorders among American Indian people: An ERP study.

Research suggests that traditional cultural factors are protective against mental health conditions in American Indian (AI) populations. This study aims to determine if cognitive control is a neurocognitive mechanism of the protective role of spirituality in AI people with generalized anxiety disorder (GAD). Participants self-identified as AI (n = 52) and included individuals with GAD (n = 16) and without GAD (n = 36).

Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation.

Hyperarousal symptoms in generalized anxiety disorder (GAD) are often incongruent with the observed physiological state, suggesting that abnormal processing of interoceptive signals is a characteristic feature of the disorder. To examine the neural mechanisms underlying interoceptive dysfunction in GAD, we evaluated whether adrenergic modulation of cardiovascular signaling differentially affects the heartbeat evoked potential (HEP), an electrophysiological marker of cardiac interoception, during concurrent electroencephalogram and functional magnetic resonance imaging (EEG-fMRI) scanning. Intravenous infusions of the peripheral adrenergic agonist isoproterenol (0.

Resilience and health in American Indians and Alaska Natives: A scoping review of the literature.

American Indians and Alaska Natives suffer from disproportionately high rates of chronic mental and physical health conditions. These health inequities are linked to colonization and its downstream consequences. Most of the American Indian and Alaska Native health inequities research uses a deficit framework, failing to acknowledge the resilience of American Indian and Alaska Native people despite challenging historical and current contexts.

Parieto-occipital ERP indicators of gut mechanosensation in humans.

Understanding the neural processes governing the human gut-brain connection has been challenging due to the inaccessibility of the body's interior. Here, we investigated neural responses to gastrointestinal sensation using a minimally invasive mechanosensory probe by quantifying brain, stomach, and perceptual responses following the ingestion of a vibrating capsule. Participants successfully perceived capsule stimulation under two vibration conditions (normal and enhanced), as evidenced by above chance accuracy scores.

Accounting for Non-Detects: Application to Satellite Ammonia Observations.

Presented is a methodology to explicitly identify and account for cloud-free satellite measurements below a sensor's measurement detection level. These low signals can often be found in satellite observations of minor atmospheric species with weak spectral signals (e.g.

DOAC Dosing Discordance Using Different Estimates of Kidney Function and Outcomes.

Direct oral anticoagulants (DOACs) are indicated for the prevention of stroke in nonvalvular atrial fibrillation. Although Food and Drug Administration labeling for DOACs uses estimated creatinine clearance according to the Cockcroft-Gault (C-G) equation, estimated glomerular filtration rate according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is often reported. The objectives of this study were to evaluate DOAC dosing discordance and to determine whether discordance based on various estimates of kidney function is associated with bleeding or thromboembolism.

Impulsivity in amphetamine use disorder: Examination of sex differences.

Aims: This study aimed to test whether there are sex differences in the relationship between impulsivity and amphetamine use disorder (AMP).

Design: A naturalistic cross-sectional design was used.

Setting: The Tulsa 1000 study was held in Tulsa, OK, USA.