Publications by authors named "Evan Siau"

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has affected our lives in a lot of different ways. We have observed a variety of clinical presentations in people infected with SARS-CoV-2 or coronavirus disease 2019 (COVID-19). Here, we present a case of COVID-19 who developed colitis ten days after an initial positive test for SARS-CoV-2.

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Article Synopsis
  • Targeted therapy for ROS1-fusion-driven non-small cell lung cancer (NSCLC) is effective, but about 19% of patients develop resistance due to MYC amplification.* -
  • Research using a patient-derived cell line demonstrated that MYC overexpression leads to significant resistance against ROS1-targeted therapy, necessitating combination treatments for better efficacy.* -
  • The study suggests combining ROS1 inhibitors with CDK4/6 inhibitors and mitochondrial inhibitors as potential strategies to overcome resistance and improve tumor control in NSCLC patients.*
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Aim: Deterioration of patients from COVID-19 is associated with cytokine release syndrome attributed to an elevation in pro-inflammatory cytokines. Vitamin D reduces proinflammatory cytokines, and has the possibility of reducing complications from respiratory tract illnesses.

Method: This was a retrospective, observational, cohort study of patients with COVID-19 disease within a New York City Health System.

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Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition RELEASE DATE: September 20, 2019 PRIOR VERSION: Not applicable DEVELOPER: American Society for Bone and Mineral Research Task Force and Multistakeholder Coalition FUNDING SOURCE: American Society for Bone and Mineral Research and the Center for Medical Technology Policy TARGET POPULATION: Adults 65 years or older with a hip or vertebral fracture. This review will focus on the core recommendations and their application in the practice of hospital medicine.

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Background: New York City emerged as an epicenter of the coronavirus disease 2019 (COVID-19) pandemic.

Objective: To describe the clinical characteristics and risk factors associated with mortality in a large patient population in the USA.

Design: Retrospective cohort study.

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Alcohol use is a common social and recreational activity in our society. Misuse of alcohol can lead to significant medical comorbidities that can affect essentially every organ system and lead to high health care costs and utilization. Heavy alcohol use across the spectrum from binge drinking and intoxication to chronic alcohol use disorder can lead to high morbidity and mortality both in the long and short term.

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Purpose: ROS1 tyrosine kinase inhibitors (TKI) provide significant benefit in lung adenocarcinoma patients with ROS1 fusions. However, as observed with all targeted therapies, resistance arises. Detecting mechanisms of acquired resistance (AR) is crucial to finding novel therapies and improve patient outcomes.

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Radiation therapy (RT) is a crucial part of cancer care, but previous work suggests that many non-radiation oncologist physicians are uncomfortable referring for RT. To evaluate training and understanding of RT, the authors sent invitations to complete an online questionnaire to all physicians at a community hospital in Bronx, NY, which asked about oncology training and self-rated and objective knowledge of RT. Out of 247 invited participants, 87 responded (35%).

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