High gonadotropin dosage does not affect euploidy and pregnancy rates in IVF PGS cycles with single embryo transfer.

Study Question: Does high gonadotropin dosage affect euploidy and pregnancy rates in PGS cycles with single embryo transfer?

Summary Answer: High gonadotropin dosage does NOT affect euploidy and pregnancy rates in PGS cycles with single embryo transfer.

What Is Known Already: PGS has been proven to be the most effective and reliable method for embryo selection in IVF cycles. Euploidy and blastulation rates decrease significantly with advancing maternal age.

Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer.

Purpose: The purpose of the present study is to examine interconnection between speed of embryo development, the genetic status of the blastocysts, and clinical outcomes in IVF preimplantation genetic screening (PGS) cycles with single embryo transfer (SET).

Methods: The retrospective comparative study has been performed between January 2013 and January 2016. Seven hundred thirty-seven cycles of IVF treatment with PGS, followed by 503 SETs, were included in the study.

Human embryos secrete microRNAs into culture media--a potential biomarker for implantation.

Objective: To determine whether human blastocysts secrete microRNA (miRNAs) into culture media and whether these reflect embryonic ploidy status and can predict in vitro fertilization (IVF) outcomes.

Design: Experimental study of human embryos and IVF culture media.

Setting: Academic IVF program.

MicroRNA expression in the human blastocyst.

Objective: To determine the most highly expressed microRNAs (miRNAs) in human blastocysts and to compare miRNAs in euploid versus aneuploid embryos and in male versus female embryos.

Design: Experimental study of human embryos: 14 blastocysts (four male, five female, and five aneuploid) were evaluated for miRNA expression with the use of an array-based quantitative real-time polymerase chain reaction (qPCR). Highly expressed and differentially expressed miRNAs were confirmed with the use of qPCR in an expanded set of 27 blastocysts (seven male, eleven female, and nine aneuploid).

Evolving role of assisted reproductive technologies.

During the past 3 decades, staggering advances have been made in the field of assisted reproductive technology (ART). This review provides an overview of the history of ART, current ART practices, and future directions within the field.

Development and testing of a vaginal pressure sensor to measure intra-abdominal pressure in women.

Aims: Elevated intra-abdominal pressure (IAP) may be a potentially modifiable risk factor for pelvic floor disorders. However, limited evidence exists due to the lack of instruments suitable to measure abdominal pressures in real world settings. The aim of this study was to develop and test a vaginal sensor prototype to measure intra-abdominal pressure in women.

Development of a novel intra-vaginal transducer with improved dynamic response.

Limitations of standard clinical pressure transducers have hampered our ability to provide reliable measurements of intra-abdominal pressure (IAP) during physical activities. To overcome these limitations, a novel intravaginal transducer (IVT) capable of accurate, reliable, and continuous IAP measurements during normal activity was developed. The design was validated through comparison with standard clinical pressure transducers in both bench top and clinical tests.