The TNFRSF members CD27 and OX40 coordinately limit T17 differentiation in regulatory T cells.

Regulatory T cells (T) are closely related to T17 cells and use aspects of the T17-differentiation program for optimal immune regulation. In several chronic inflammatory human diseases, T express IL-17A, suggesting that dysregulation of T17-associated pathways in T may result in either loss of suppressive function and/or conversion into pathogenic cells. The pathways that regulate the T17 program in T are poorly understood.