Publications by authors named "Evan D Buckley"
Background: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment being employed frequently for radiographically progressive brain metastases. Considerable interest exists in combining LITT-mediated in situ vaccination to license immune checkpoint blockade (ICB). No studies have examined the clinical feasibility of this combination in brain metastases.
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- The study investigates the risk of radiation necrosis (RN) in patients with HER2+ breast cancer brain metastasis who underwent stereotactic radiosurgery (SRS) while receiving systemic therapies.
- It involves a review of 46 patients treated at a single institution from 2013 to 2018, with 28 patients (60.9%) developing RN within a year post-SRS.
- Results indicate that those who developed RN were more likely to have received multiple HER2-directed therapies during their treatment compared to those who did not develop RN, suggesting a potential correlation between systemic therapy type and timing with RN risk.
Purpose: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases.
Methods And Materials: Adult patients with 4 to 10 brain metastases were eligible for this prospective trial. The primary endpoint was overall survival.
Article Synopsis
- This study focuses on primary brain tumor (PBT) patients in intensive care units (ICUs), highlighting their outcomes which are not well-researched.
- A total of 59 PBT patients were analyzed, revealing an ICU mortality rate of 19%, with seizures being the most common reason for admission (27%).
- The ICU mortality rate for PBT patients was found to be similar to other solid tumor patients and the general ICU population, suggesting the need for larger studies to improve care guidelines for PBT patients in ICU settings.