Biophysically detailed simulations of neuronal activity often rely on solving large systems of differential equations; in some models, these systems have tens of thousands of states per cell. Numerically solving these equations is computationally intensive and requires making assumptions about the initial cell states. Additional realism from incorporating more biological detail is achieved at the cost of increasingly more states, more computational resources, and more modeling assumptions.
View Article and Find Full Text PDFEvol Bioinform Online
September 2018
With the daily release of data from whole genome sequencing projects, tools to facilitate comparative studies are hard-pressed to keep pace. Graphical software solutions can readily recognize synteny by measuring similarities between sequences. Nevertheless, regions of dissimilarity can prove to be equally informative; these regions may harbor genes acquired via lateral gene transfer (LGT), signify gene loss or gain, or include coding regions under strong selection.
View Article and Find Full Text PDFHere, we report the draft genome sequence for the type strain (Winslow and Winslow) Evans (ATCC 14990). The assembly consisted of 2,457,519 bp with an observed G+C content of 32.04%.
View Article and Find Full Text PDFDraft genome sequences for subsp. Rosenbach ATCC 14458 and ATCC 27217 strains were investigated. The genome sizes were 2,880,761 bp and 2,759,100 bp, respectively.
View Article and Find Full Text PDFThe actinobacterium can be found in a wide variety of habitats. Here, we report the 2,411,958-bp draft genome sequence of the type strain (Schroeter) Cohn (ATCC 12698). Characteristic of this taxa, the genome sequence has a high G+C content, 73.
View Article and Find Full Text PDFWhile a part of the native gut microflora, the Gram-positive bacterium can lead to serious infections elsewhere in the body. The draft genome of strain ATCC BAA-2128, isolated from piglet feces, was examined. This draft genome consists of 42 contigs, 12 of which exhibit homology to annotated plasmids.
View Article and Find Full Text PDF