Publications by authors named "Evan Corden"
Article Synopsis
- Mitochondria don't use nucleotide excision DNA repair, but their DNA (mtDNA) shows resilience against mutations after DNA damage, hinting at protective mechanisms.
- Research involved techniques like live-cell imaging and protein-DNA binding assays to study how Transcription Factor A, Mitochondrial (TFAM) interacts with UVC-damaged DNA and its effects on mtDNA.
- Results showed TFAM increases mtDNA compaction when damaged, but surprisingly, this doesn't prevent further DNA damage or mutations, suggesting TFAM's role as a damage sensor rather than a protective agent.
