Publications by authors named "Evan Brown"

Article Synopsis
  • The study aimed to explore the effectiveness of phosphonoformic acid (PFA) and Dynasore in preventing medication-related osteonecrosis of the jaw by blocking bisphosphonates' entry into human gingival fibroblasts (HGFs).
  • The researchers found that while PFA did not protect HGFs from the harmful effects of zoledronate (ZOL), Dynasore successfully prevented cell death when exposed to ZOL and inhibited the macropinocytosis process.
  • Overall results indicated that Dynasore was effective in blocking ZOL entry and preventing endosomal acidification, suggesting it could be a potential treatment option for managing medication-related osteonecrosis of the jaw.
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The development and use of virtual laboratories to augment traditional in-person skills training continues to grow. Virtual labs have been implemented in a number of diverse educational settings, which have many purported benefits including their adaptability, accessibility, and repeatability. However, few studies have evaluated the impact of virtual laboratories outside of academic achievement and skills competencies, especially in biotechnology.

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Analysis of streamlined computational models used to predict androgen disrupting chemicals revealed that assays measuring androgen receptor (AR) cofactor recruitment/dimerization were particularly indispensable to high predictivity, especially for AR antagonists. As the original dimerization assays used to develop the minimal assay models are no longer available, new assays must be established and evaluated as suitable alternatives to assess chemicals beyond the original 1,800+ supported by the current data. Here we present the AR2 assay, which is a stable, cell-based method that uses an enzyme complementation approach.

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Effective insect pollination requires appropriate responses to internal and external environmental cues in both the plant and the pollinator. Helianthus annuus, a highly outcrossing species, is marked for its uniform eastward orientation of mature pseudanthia, or capitula. Here we investigate how this orientation affects floral microclimate and the consequent effects on plant and pollinator interactions and reproductive fitness.

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Background: Vasoactive and inotropic support (VIS) may predispose cardiac surgery patients to ischemic gut complications (IGCx). The purpose of this study was to describe the effect of VIS on the manner in which we deliver tube feeds (TFs) and determine its relationship with IGCx in cardiac surgery patients.

Methods: We reviewed cardiac surgery patients at a single institution and examined the effect of VIS (none, low, medium, high) on TF administration and evaluated IGCx.

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Objective: The objective of this study was to investigate the effect of mechanical strain by mapping physicochemical properties at periodontal ligament (PDL)-bone and PDL-cementum attachment sites and within the tissues .

Design: Accentuated mechanical strain was induced by applying a unidirectional force of 0.06N for 14 days on molars in a rat model.

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Healthcare providers using social media must remain mindful of professional boundaries and patients' privacy rights. Facebook and other online postings must comply with the Health Insurance Portability and Accountability Act of 1996 (HIPAA), applicable facility policy, state law, and AANA's Code of Ethics.

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