Publications by authors named "Evan Bradner"
Discontinuation of Transmission Precautions for COVID-19 Patients: Polymerase Chain Reaction Diagnostics, Patient Delays, and Cycle Threshold Values.
Infect Dis Clin Pract (Baltim Md)
September 2021
Article Synopsis
- The study explores the challenges in determining when to safely discontinue transmission-based precautions for hospitalized COVID-19 patients, highlighting the contrasting guidelines from the CDC.
- A review of 196 patients revealed that many faced delays in leaving isolation due to repeated positive PCR tests, resulting in extended hospital stays and significant costs.
- The findings suggest that clinicians should consider additional data, such as cycle threshold (Ct) values from PCR tests, to make better-informed decisions on discontinuing precautions, especially for potentially contagious patients.
Hypoxia presents a challenge to anticancer therapy, reducing the efficacy of many available treatments. Photodynamic therapy is particularly susceptible to hypoxia, given that its mechanism relies on oxygen. Herein, we introduce two new osmium-based polypyridyl photosensitizers that are active in hypoxia.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied a series of modified Ru(II) complexes to evaluate their anticancer potential in low-oxygen (hypoxic) environments.
- These complexes featured specially designed ligands, allowing for altered photochemical behaviors and impacts on cancer cell toxicity when exposed to specific light wavelengths.
- Notably, one complex maintained effectiveness in hypoxic conditions, demonstrating a high photocytotoxicity index (PI) compared to typical Ru(II) complexes, highlighting its potential for targeted cancer therapies.
Article Synopsis
- A new class of cyclometalated ruthenium(II) compounds featuring π-extended benzo[ h]imidazo[4,5-f]quinoline ligands was studied for their photophysical and photobiological properties, showing positive octanol-water partition coefficients that increased with the number of thienyl rings.
- These compounds exhibited noticeable shifts in absorption and emission energies compared to traditional Ru(II) complexes, with distinct fluorescence and phosphorescence behavior that varied with different ligands.
- In terms of cytotoxicity, some compounds displayed selective toxicity towards melanoma cells, with compound 4 being nontoxic and compound 3 showing high potency, highlighting their potential as targeted chemotherapeutic agents based