Effects of structured exercise training on miRNA expression in previously sedentary individuals.

Introduction: Micro ribonucleic acids (miRNA) respond to acute bouts of vigorous exercise, such as maximal cardiopulmonary exercise tests (CPET), by expressing an anti-atherogenic, anti-inflammatory and hence probably ergogenic profile. However, the impact of long-term engagement in physical exercise on CPET-induced miRNA response in sedentary individuals, with subsequent increased risk for cardiovascular diseases, remains unclear.

Methods: Thirty-four sedentary participants underwent CPET before and after a four-month app-assisted exercise intervention, during which the moderate to vigorous physical activity (MVPA) was increased to over 150 min/week.

Making it transparent: A worked example of articulating programme theory for a digital health application using Intervention Mapping.

Objective: Digital health interventions for behaviour change are usually complex interventions, and intervention developers should 'articulate programme theory', that is, they should offer detailed descriptions of individual intervention components and their proposed mechanisms of action. However, such detailed descriptions often remain lacking. The objective of this work was to provide a conceptual case study with an applied example of 'articulating programme theory' for a newly developed digital health intervention.

Investigating shared decision-making during the use of a digital health tool for physical activity planning in cardiac rehabilitation.

Background: Shared decision making (SDM) between healthcare professionals and persons with CVD can have a positive impact on motivation, adherence, or sustainability regarding long-term goals and integration of cardiovascular disease (CVD) rehabilitation in the everyday lives of persons with CVD. SDM can foster the transition between regular heart-healthy activity at rehabilitation facilities and more independent activity at home, but it is often challenging to implement SDM given limited time and resources, e.g.

The Development of a Digital Tool for Planning Physical Exercise Training During Cardiac Rehabilitation.

In this work, we describe the conceptualization and development of a digital tool to support patients in adhering to prescription of physical exercise training during cardiac rehabilitation. To meet the need for an individual and trackable heart-healthy training plan - which became even more evident during the Coronavirus pandemic - the Activity Planning Tool was developed within a user-centered design process. Tackling the relationship between rehabilitation professional and patient, it allows to jointly set up, monitor, and regularly review a personalized physical activity plan.

General Data Protection Regulation (GDPR) Toolkit for Digital Health.

The General Data Protection Regulation (GDPR) entered into force on May 25, 2018. Compliance with GDPR is especially relevant to the Digital Health (DH) domain, as it is common to process highly sensitive personal data regarding a person's health. However, GDPR compliance is a very challenging process since it requires implementing several technical and organizational measures to maintain compliance.