Publications by authors named "Eva Yebra-Fernandez"
Article Synopsis
- * Utilizing next-generation sequencing (NGS), researchers conducted a large-scale short hairpin RNA (shRNA) knockdown screen on nearly 5,000 genes from primary AML cells, focusing on gene knockdown across multiple timepoints for accuracy.
- * The analysis revealed NOX1 as a critical gene with significant knockdown impact on leukaemia cell survival, making NOX family genes promising targets for developing new AML therapies.
The development of assays for evaluating the sensitivity of leukaemia cells to anti-cancer agents is becoming an important aspect of personalized medicine. Conventional cell cultures lack the three-dimensional (3D) structure of the bone marrow (BM), the extracellular matrix and stromal components which are crucial for the growth and survival of leukaemia stem cells. To accurately predict the sensitivity of the leukaemia cells in an assay a culturing system containing the essential components of BM is required.
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