[Sleep and circadian rhythms].

The sleep-wake regulatory system and the circadian rhythm generating system are two brain networks integrated in the classical two-process model. These processes interact continuously, and to obtain an optimal sleep they must be correctly aligned. The suprachiasmatic nucleus located in the hypothalamus is crucial in the regulation of circadian rhythms, and the hypothalamus is a key component of the sleep-wake regulatory system in association with the thalamus, basal forebrain and brainstem.

Morbidity and mortality of middle-aged and elderly narcoleptics.

Objectives: The objective of the study was to evaluate the morbidities and mortality in a national group of middle-aged and elderly narcolepsy patients before and after the first diagnosis of the condition.

Methods: From the Danish National Patient Registry (NPR), 1174 patients (45.1% males) aged 20-59 years and 339 patients (44.

Morbidity of childhood onset narcolepsy: a controlled national study.

Unlabelled: Narcolepsy is associated with significant morbidities. We evaluated the morbidities and mortality in a national group of child and adolescent patients after a first diagnosis of narcolepsy.

Methods: Identified from the Danish National Patient Registry (NPR), 243 patients (128 boys) aged 0-19 years diagnosed with narcolepsy between 1998 and 2012 with follow-up until 2014 were compared with 970 controls who were randomly chosen from the Danish Civil Registration System Statistics and matched by age, gender and geography.