Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.

The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction is a key-characteristic of clinical AAA disease. We hypothesize that doxycycline impairs mitochondrial function in the aorta and aortic smooth muscle cells (SMCs).

Hemodynamic Response to Fluid Boluses for Hypotension in Children in a Cardiac ICU.

Objectives: To describe the hemodynamic response to fluid boluses for hypotension in children in a cardiac ICU.

Design: A prospective, observational study.

Setting: Single-centered cardiac ICU.

[Neonatal sepsis caused by group B streptococci: atypical and recurrent disease episodes].

Both neonates of male twins born at 30 weeks and 3 days gestation presented with late-onset sepsis caused by an infection with group B streptococci (GBS), shortly after one another. Although the younger twin recovered with a standard regimen of 10 days penicillin G i.v.

Gender, age, and educational level attribute to blood alcohol concentration in hospitalized intoxicated adolescents; a cohort study.

Background: The prevalence of adolescents hospitalized with acute alcohol intoxication, mainly because of severe reduced consciousness, is increasing. However, the characteristics of these adolescents are mainly unidentified. In this clinical research, we aimed to identify factors that attribute to higher ethanol concentration, on which targeted alcohol health interventions can be designed.