Specific surface, crystallinity, and dissolution of lyophilized fibrinogen. A study by combined small- and wide-angle X-ray scattering (SWAXS).

The nano-structural properties of six different batches of lyophilized fibrinogen at various contents of residual humidity (6-20%) were studied by small- and wide-angle X-ray scattering (SWAXS) and related to the dissolution properties. As structural parameters, the specific surface and relative degree of crystallinity, from SAXS and WAXS, respectively, were used, and correlated to the dissolution rates. BET surface area and electron microscopy were used as ancillary methods.