Publications by authors named "Eva Santruckova"
Article Synopsis
- Xanomeline preferentially activates M1 and M4 muscarinic receptors, showing unique reversible and wash-resistant binding properties, with selectivity mechanisms still unclear.
- Short-term exposure to xanomeline increases intracellular calcium for M1 and M4 receptors, while not causing internalization like other agonists, indicating a different activation pathway.
- The study reveals that xanomeline acts as a long-term antagonist at M5 receptors and demonstrates that its effectiveness is higher for M1 and M4, suggesting specialized activation mechanisms for these receptors.
Adenosine receptors (AR) belonging to the G protein-coupled receptor family influence a wide range of physiological processes. Recent elucidation of the structure of human A2AR revealed the conserved amino acids necessary for contact with the Ado moiety. However, the selectivity of Ado analogs for AR subtypes is still not well understood.
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