Proteomic analysis of p16ink4a-binding proteins.

The p16(ink4a) tumor suppressor protein plays a critical role in cell cycle control, tumorogenesis and senescence. The best known activity for p16(ink4a) is the inhibition of the activity of CDK4 and CDK6 kinases, both playing a key role in cell cycle progression. With the aim to study new p16(ink4a) functions we used affinity chromatography and MS techniques to identify new p16(ink4a)-interacting proteins.

Short-term effects and teratogenicity of heptanol on embryos of Xenopus laevis.

This study examined teratogenic and short-term effects of heptanol on Xenopus embryos. Embryos were exposed for 5h to 2.5mM heptanol at different developmental stages.