[The hospital transfer of a patient with gastrointestinal bleeding from oesophageal varices].

The care of patients with gastrointestinal bleeding from oesophageal varices during inter-hospital transfer is a complex procedure to different causes. Some of these include, the high number of parameters to take into account, the monitoring of the electro-medical equipment, the instability of the patient and their needs or the short time available to know the patient and obtain the maximum information in order to plan a safe and proper transfer. The main role of the nurse in the transfer of critically ill patients focuses on the control and monitoring of all these aspects and the maintenance of the continuity of the caring initiated in the hospital.

Increase of R-/S-methadone enantiomer concentration ratio in serum of patients treated with either nevirapine or efavirenz.

An increased methadone enantiomer ratio (R/S) was associated to both nevirapine (179%, n=5) and efavirenz (36%, n=9) treatments when compared with that of controls (n=52). Additionally, in four follow-up patients, both R- and S-methadone normalized concentrations decreased (19%-93%) while R/S increased (22%-314%) following nevirapine/efavirenz treatment. R/S decreased (42%) after non-compliance with efavirenz treatment.

Detection of clinical interactions between methadone and anti-retroviral compounds using an enantioselective capillary electrophoresis for methadone analysis.

A capillary electrophoresis method was developed to detect interactions between methadone and anti-retroviral compounds. Eight subjects, who underwent methadone maintenance treatment in the Province of Alicante (Spain), consented to participate in the present study. Of those, one subject was followed up for 123 days to detect drug-drug interactions.