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Publications by authors named "Eva Meunier"

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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.
Wladimir Malaga Delphine Payros Eva Meunier Wafa Frigui Fadel Sayes

PLoS Pathog

July 2023

Article Synopsis
  • The study investigates the genetic differences between Mycobacterium tuberculosis (MTB) and its ancestor, Mycobacterium canettii, focusing on the PhoPR regulatory system that influences virulence.
  • Mutations in the phoR gene of M. canettii affect PhoP expression and pathogenicity, with the most attenuated strain (STB-K) showing lower expression of PhoP-regulated genes compared to MTB.
  • Gene swapping experiments reveal that the MTB phoPR allele enhances virulence traits in M. canettii, indicating that variations in PhoR have played a role in the evolution of MTB’s increased pathogenicity and ability to persist in hosts.
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