Publications by authors named "Eva M Sevick"
Article Synopsis
- - EPHB4 and RASA1 are essential for the formation and maintenance of lymphatic vessel (LV) valves during development, but how they interact in this process is not fully understood.
- - The study used both genetically modified mice and human lymphatic endothelial cells to show that disrupting EPHB4 or RASA1 significantly impairs LV valve specification and development, which can be countered by targeting the Ras-MAPK signaling pathway.
- - The findings indicate that proper function of EPHB4 and RASA1 is crucial for successful LV valve development, with potential implications for understanding lymphatic diseases or conditions related to valve dysfunction.
EPHB4 is a receptor protein tyrosine kinase that is required for the development of lymphatic vessel (LV) valves. We show here that EPHB4 is necessary for the specification of LV valves, their continued development after specification, and the maintenance of LV valves in adult mice. EPHB4 promotes LV valve development by inhibiting the activation of the Ras-MAPK pathway in LV endothelial cells (LEC).
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