Publications by authors named "Eva M Becker-Pelster"
Background: Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase. Here we describe a new inhaled soluble guanylate cyclase activator to target apo-soluble guanylate cyclase and outline its therapeutic potential.
Methods: We aimed to generate a novel soluble guanylate cyclase activator, specifically designed for local inhaled application in the lung.