Publications by authors named "Eva Larkai"
Objective: Our objective was to codesign, implement, evaluate acceptability and refine an optimised antenatal education session to improve birth preparedness.
Design: There were four distinct phases: codesign (focus groups and codesign workshops with parents and staff); implementation of intervention; evaluation (interviews, questionnaires, structured feedback forms) and systematic refinement.
Setting: The study was set in a single maternity unit with approximately 5500 births annually.
Article Synopsis
- - The study investigates the mechanisms behind Shiga toxin-producing E. coli hemolytic uremic syndrome (STEC-HUS), a leading cause of acute kidney injury in children, revealing that the glomerular microvasculature is particularly vulnerable to damage from systemic Stx infection.
- - Researchers engineered mice to express the Stx receptor in kidney cells and found that exposure led to reduction of a crucial growth factor (VEGF-A), causing more damage via complement pathway activation.
- - The findings suggest that early intervention using a C5 inhibitor could be a promising treatment to mitigate the effects of STx-induced HUS, enhancing understanding of the disease's targeting of the kidneys.
Tocolytics for delaying preterm birth: a network meta-analysis (0924).
Cochrane Database Syst Rev
August 2022
Background: Preterm birth is the leading cause of death in newborns and children. Tocolytic drugs aim to delay preterm birth by suppressing uterine contractions to allow time for administration of corticosteroids for fetal lung maturation, magnesium sulphate for neuroprotection, and transport to a facility with appropriate neonatal care facilities. However, there is still uncertainty about their effectiveness and safety.
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