Publications by authors named "Eva Korup"
Article Synopsis
- * Out of 1116 trial participants, women showed lower rates of all-cause and cardiovascular mortality compared to men, yet ICDs did not significantly reduce mortality rates for either sex.
- * Both men and women had a reduced risk of sudden cardiovascular death with ICDs, but there was no overall survival advantage from ICD implantation in patients with nonischemic systolic heart failure.
Article Synopsis
- This study extended the follow-up of the DANISH trial, focusing on how baseline NT-proBNP levels affect the outcomes of implantable cardioverter-defibrillator (ICD) implantation in patients with non-ischemic systolic heart failure.
- The data showed that patients with lower NT-proBNP levels (below the median) had a significant reduction in all-cause mortality and cardiovascular deaths with ICD compared to standard care, while those with higher levels did not see similar benefits.
- The findings suggest that lower NT-proBNP levels could help identify patients who are more likely to benefit from ICD implantation in treating their heart failure.
Article Synopsis
- The study investigates how periodic repolarization dynamics (PRD) can identify nonischemic cardiomyopathy patients who might benefit from getting a cardioverter-defibrillator (ICD) implanted as a preventive measure against sudden cardiac events.
- A post hoc analysis of the DANISH trial included patients with severe heart function issues (LVEF ≤35% and high NT-proBNP levels) to see how baseline PRD, measured using 24-hour Holter monitors, related to their mortality.
- Results showed that higher PRD was linked to higher mortality in patients not receiving ICDs, while there was no significant link in those with ICDs, suggesting that PRD could help target patients who would benefit most from ICD therapy
Article Synopsis
- * Researchers analyzed data from 850 patients with severe heart failure, monitoring their heart for 24 hours to find indicators like non-sustained ventricular tachycardia (NSVT) and the burden of premature ventricular contractions (PVCs).
- * Results showed that while both NSVT and high PVC burden were linked to higher overall mortality and cardiovascular death, they did not help in predicting which patients would benefit from ICD implantation.
Article Synopsis
- Atrial fibrillation (AF) and excessive supraventricular ectopic activity (ESVEA) in patients with nonischemic heart failure (HF) were linked to higher mortality rates, including all-cause and cardiovascular deaths.
- In a study of 850 patients, 22% had AF and 10% had ESVEA, with both conditions leading to significantly increased risks of death over nearly five years of follow-up.
- The implantation of a prophylactic implantable cardioverter defibrillator (ICD) did not show any improvement in outcomes for patients with AF or ESVEA, indicating that management strategies may need re-evaluation.
Aims: Implantable cardioverter-defibrillator (ICD) implantation reduce the risk of sudden cardiac death, but not all-cause death in patients with non-ischaemic systolic heart failure (HF). Whether co-existence of diabetes affects ICD treatment effects is unclear.
Methods And Results: We examined the effect of ICD implantation on risk of all-cause death, cardiovascular death, and sudden cardiac death (SCD) according to diabetes status at baseline in the Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischaemic Systolic Heart Failure on Mortality (DANISH) trial.
Article Synopsis
- The Danish Study (DANISH) aimed to evaluate the impact of implantable cardioverter-defibrillators (ICD) on health-related quality of life (HRQoL) in patients with non-ischaemic systolic heart failure, despite finding no overall effect on mortality.
- In the study, 1116 patients were randomly assigned to receive either ICD implantation or standard care, with HRQoL assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) over 8 months.
- Results indicated that there were no significant differences in HRQoL improvements between the ICD group and the control group, suggesting that ICD implantation did not enhance quality of life for these patients.
Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S.
View Article and Find Full Text PDFBackground: The DANISH study (Danish Study to Assess the Efficacy of ICDs [Implantable Cardioverter Defibrillators] in Patients With Non-Ischemic Systolic Heart Failure on Mortality) did not demonstrate an overall effect on all-cause mortality with ICD implantation. However, the prespecified subgroup analysis suggested a possible age-dependent association between ICD implantation and mortality with survival benefit seen only in the youngest patients. The nature of this relationship between age and outcome of a primary prevention ICD in patients with nonischemic systolic heart failure warrants further investigation.
View Article and Find Full Text PDFBackground: The effect of an implantable cardioverter defibrillator (ICD) in patients with symptomatic systolic heart failure (HF) caused by coronary artery disease is well documented. However, the effect of primary prophylactic ICDs in patients with systolic HF not due to coronary artery disease is much weaker. In addition, HF management has improved, since the landmark ICD trials and a large proportion of patients now receive cardiac resynchronization therapy (CRT) where the effect of ICD treatment is unknown.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the impact of implantable cardioverter-defibrillators (ICDs) on patients with symptomatic systolic heart failure not caused by coronary artery disease, comparing ICD treatment with usual clinical care.
- A total of 1,116 patients were enrolled, and after 67.6 months, it was found that ICDs did not significantly lower overall mortality rates compared to the control group, although they did reduce instances of sudden cardiac death.
- The findings suggest that while ICDs may have benefits for sudden cardiac death prevention, they do not significantly improve long-term survival rates in this specific patient population.
We report Aspergillus delacroxii (formerly Aspergillus nidulans var. echinulatus) causing recurrent prosthetic valve endocarditis. The fungus was the sole agent detected during replacement of a mechanical aortic valve conduit due to abscess formation.
View Article and Find Full Text PDFBackground: Guidelines for the treatment of left-sided infective endocarditis (IE) recommend 4 to 6 weeks of intravenous antibiotics. Conversion from intravenous to oral antibiotics in clinically stabilized patients could reduce the side effects associated with intravenous treatment and shorten the length of hospital stay. Evidence supporting partial oral therapy as an alternative to the routinely recommended continued parenteral therapy is scarce, although observational data suggest that this strategy may be safe and effective.
View Article and Find Full Text PDFAims: Staphylococcus aureus infective endocarditis (IE) is a critical medical condition associated with a high morbidity and mortality. In the present study, we prospectively evaluated the importance of screening with echocardiography in an unselected S. aureus bacteraemia (SAB) population.
View Article and Find Full Text PDFEndocarditis and localized pocket infections are recognized as serious adverse events in patients with implanted cardiac impulse generators. We have undertaken a 10-y retrospective study in North Denmark Region (population 0.5 million) in order to elucidate the clinical spectrum, causative microorganisms, management and outcome.
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