Publications by authors named "Eva K Merzel Sabovic"

Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantly to increased cardiovascular risk. While various treatments completely clear the skin, the associated effects on systemic inflammation are not yet clear.

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Article Synopsis
  • Endothelial dysfunction is linked to atherosclerosis and is common in psoriasis patients due to inflammation; this study focused on young patients with psoriasis vulgaris after effective treatment.
  • Researchers measured endothelial function, arterial stiffness, and specific biomarkers in 80 treated psoriasis patients and 20 healthy controls, finding no significant differences between the groups.
  • The findings suggest that effective psoriasis treatment may have a cardioprotective effect, potentially reducing cardiovascular risks associated with the condition.
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Article Synopsis
  • Metabolic disorders are prevalent among psoriasis patients, increasing their risk for cardiovascular issues, but the effect of biologic therapies on these metabolic parameters is unclear.
  • A study involving 80 young psoriasis patients treated with various biologics and 20 healthy controls revealed no significant metabolic differences between the treated patients and the controls.
  • The findings suggest that young psoriasis patients successfully treated with biologics experience no significant residual metabolic burden, similar to those treated with topical therapy or methotrexate, which is important for their overall treatment approach.
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Background: Sarcoidosis is a multisystemic disease characterized by granulomatous inflammation. Sarcoidosis often poses a diagnostic challenge owing to its nonspecific or mild clinical features. In 20-35% of cases, sarcoidosis initially presents on skin.

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Menopause is a state of estrogen deficiency that affects numerous estrogen-dependent tissues in the female body. Skin is one of the most affected organs. Many consider menopausal skin changes to be merely an aesthetic problem; however, they can significantly affect women's quality of life.

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Spitz lesions represent a spectrum of melanocytic proliferations, and they include Spitz nevi, atypical Spitz tumors, and Spitz melanomas. Atypical Spitz tumors are intermediate melanocytic lesions with features between benign Spitz nevi and malignant Spitz melanomas. They often present a diagnostic challenge to pathologists and dermatologists alike because they can mimic melanoma, especially high-grade atypical Spitz tumors.

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Dystrophic epidermolysis bullosa inversa is a very rare subtype of inherited dystrophic epidermolysis bullosa with a unique clinical manifestation. Generalized blistering in the neonatal period and in early infancy improves with age, with lesions becoming restricted to intertriginous areas, axial parts of the trunk, and mucous membranes. In contrast to other variants of dystrophic epidermolysis bullosa, the inverse type has a more favorable prognosis.

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Psoriasis is a chronic systemic inflammatory disease. Due to systemic inflammation, it is associated with many comorbidities. Among them, cardiovascular diseases represent the most common causes of morbidity and mortality in this population.

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Acquired epidermodysplasia verruciformis is a rare disease. It can develop in immunocompromised patients due to infection with human papillomaviruses. Because such patients are at high risk of developing cutaneous squamous cell carcinoma, timely diagnosis and regular monitoring of the patient is essential.

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Perianal skin lesions are present in a significant portion of dermatology patients. It is therefore important for every dermatologist to be familiar with a wide range of differential diagnoses and to treat the underlying cause in a timely manner. Here we present the case of a 24-year-old male with perianal ulceration due to a newly diagnosed herpes simplex virus infection.

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Angiokeratomas are the cutaneous hallmark of Fabry disease. Although it is well established that enzyme replacement therapy (ERT) prevents or slows the progression of disease on target organs in the majority of patients, the long-term effect of ERT on angiokeratomas remains unknown. We present a patient diagnosed with Fabry disease at age 11, with rapid progression of new angiokeratomas in typical regions before beginning treatment with ERT.

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Hand, foot, and mouth disease is a highly contagious disease that predominantly affects children under the age of five. The illness is much less common in adults and often presents with atypical skin lesions. Here we describe the case of a 19-year-old healthy, immunocompetent male patient with atypical clinical presentation, with a macular rash on the scalp, palms, soles, and shins, and with minimal lesions in the oral cavity.

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