Publications by authors named "Eva H Spodsberg"
Background: In people, studies have shown that resistance to fibrinolysis could be a contributing factor to thrombosis. Tissue-plasminogen-activated (t-PA) thromboelastography (TEG) has been used to evaluate endogenous fibrinolytic potential. In dogs, TEG has been used for the diagnosis of various hemostatic disorders, but studies evaluating fibrinolysis are limited.
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- The first cases of early-onset progressive polyneuropathy in Alaskan Malamutes were identified in Norway during the late 1970s, initially affecting both male and female dogs, leading to severe mobility issues.
- Genetic analysis revealed a harmful mutation in the NDRG1 gene in affected dogs, specifically a Gly98Val substitution linked to the disease.
- This discovery not only establishes a potential genetic cause for the condition in Alaskan Malamutes but also presents a new model for understanding similar human neuropathies and the possibility of selective breeding to reduce the mutation's prevalence.
Evaluation of platelet aggregometry in dogs using the Multiplate platelet analyzer: impact of anticoagulant choice and assay duration.
J Vet Emerg Crit Care (San Antonio)
February 2012
Objective: To investigate the performance of the Multiplate platelet function analyzer with regards to: (1) the use of 3 different anticoagulants (ie, citrate, hirudin, and heparin) and (2) the evaluation of optimal assay time.
Design: Prospective observational in vitro study.
Setting: University veterinary teaching hospital.