[The temporal accuracy of agomelatine administration and comparison of antidepressant effect of agomelatine and escitalopram in major depression: a retrospective investigation at a psychiatric outpatient clinic].

Aim: The assessment of antidepressant efficacy of agomelatine, a new chronobiological type of antidepressant as a function of the temporal accuracy of administration, compared to the antidepressive effect of escitalopram.

Methods: In our retrospective study at the end of a 12-week treatment improvement rates were analysed in all depressed patients attending our ourpatient clinic receiving agomelatine (25 or 50 mg daily) or escitalopram (10 or 20 mg daily) monotherapy initiated between 01. 03.