Publications by authors named "Eva Falkensammer"
Minerva Urol Nephrol
November 2024
Article Synopsis
- - The study aimed to analyze factors affecting postoperative renal function (PRF) following robot-assisted partial nephrectomy for patients with multiple kidney tumors, using data from 132 surgeries and assessing both patient and surgical influences on outcomes.
- - Key findings included that most patients had two tumors, the average surgery lasted 175 minutes, and that the majority of surgeries met trifecta criteria, indicating successful outcomes in terms of cancer control, renal preservation, and complications.
- - Factors such as warm ischemia time, body mass index (BMI), and preoperative kidney function were found to impact kidney function loss post-surgery, with BMI and comorbidities being significant predictors of acute kidney injury during hospitalization.
Antibiotics (Basel)
May 2024
Article Synopsis
- Urinary tract infections (UTIs) are common complications for kidney transplant recipients, with asymptomatic bacteriuria (ASB) potentially increasing the risk of both UTIs and graft rejection.
- A systematic literature review was conducted analyzing studies that focused on the management of ASB after kidney transplantation, with specific attention to screening and treatment protocols during the first year post-transplant.
- The review found no solid evidence indicating benefits from treating ASB, as studies showed no increased risk of UTIs, acute kidney problems, or mortality in patients who did not receive antibiotic treatment for ASB, likely due to unaccounted confounding factors in the studies.
Antibiotics (Basel)
December 2023
Article Synopsis
- The study examines whether antibiotic prophylaxis (AP) is beneficial during robot-assisted laparoscopic radical prostatectomy (RALP) for prostate cancer, highlighting concerns over antibiotic resistance and side effects.
- A systematic literature review reviewed 436 publications, ultimately finding 8 relevant studies involving 6,378 RALP procedures, yet no substantial evidence showed effective differences in infection rates based on varying AP protocols.
- Overall, infection rates post-surgery ranged from 0.6% to 6.6%, but the lack of scientific proof for AP's efficacy suggests a need for more uniform research to provide better guidance on its use in RALP.
Article Synopsis
- Histone deacetylases (HDACs) are often elevated in cancer and targeted for therapy, but inhibiting them can also weaken the immune response, allowing tumors to evade detection.
- A study on HDAC5-deficient mice showed that while they don’t develop autoimmune diseases, their T-regulatory cells lose suppressive function and struggle to form effectively.
- Ultimately, targeting HDAC5 did not enhance anticancer immunity, as CD8(+) T cells showed decreased cytokine production, indicating a complex relationship between HDAC5, immune cell function, and cancer response.
