A pharmacogenetic association between a variation in calpain 10 (CAPN10) gene and the response to metformin treatment in patients with type 2 diabetes.

Purpose: The aim of the present study was to investigate possible associations of the single-nucleotide variants in six genes encoding the key molecules mediating the metformin pharmacodynamic effect with the response to treatment with metformin in patients with type 2 diabetes.

Methods: One hundred forty-eight drug-naïve patients with type 2 diabetes were included in the study. PRKAA1 rs249429, STK11 rs741765, PCK1 rs4810083, PPARGC1A rs10213440, HNF1A rs11086926, and CAPN10 rs3792269 variants were genotyped.

4-(Adamantan-1-yl)-2-(4-fluoro-phen-yl)quinoline.

In the mol-ecule of the title compound, C25H24FN, the dihedral angle between the best planes of the quinoline fragment (rings A and B) and the benzene ring (C) is 9.51 (4)°. In the crystal, mol-ecules are linked into centrosymmetric dimers via pairs of weak C-H⋯F inter-actions.

Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide.

Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas. All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel. The aim of the present study was to compare TCF7L2 genotype specific effect of gliclazide binding to KATP channel A-site (Group 1) with sulfonylureas binding to AB-site (Group 2).

2-(Adamantan-1-yl)-1,3-bis-(4-methyl-phen-yl)propan-2-ol.

The conformation of the title compound, C27H34O, is stabilized by a weak intra-molecular C-H⋯π inter-action. The dihedral angle between the benzene rings is 54.79 (4)°.

KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.

Aims: Potassium inwardly rectifier 6.2 subunit (Kir6.2) of the ATP-sensitive potassium (K(ATP)) channel encoded by KCNJ11 gene is a therapeutical target for sulfonylureas.

(1-Adamant-yl)(2-methyl-phen-yl)methanone.

In the title compound, C(18)H(22)O, the dihedral angle between the carbonyl and benzene planes is 69.11 (6)°. In the adamantyl group, the three fused cyclo-hexane rings have almost ideal chair conformations, with C-C-C angles in the range 108.

2-(1-Adamant-yl)-1,3-diphenyl-propan-2-ol.

In the title compound, C(25)H(30)O, the adamantane cage consists of three fused cyclo-hexane rings in classical chair conformations, with C-C-C angles in the range 107.15 (9)-111.55 (9)°.

3-(1-Adamant-yl)-6-methyl-3-(3-methyl-benz-yl)isochroman-1-one.

In the title compound, C(28)H(32)O(2), the oxanone ring adopts distorted half-boat conformation with the following Cremer and Pople puckering parameters: Q = 0.619 (2) Å, θ = 0.75 (19) and ϕ = 172 (13)°.