Angiotensin involvement in kidney injury induced by rheumatoid arthritis in rat.

Renal injury induced by rheumatoid arthritis is not clear and may be related to the angiotensin II. We aim to investigate the adjuvant-induced arthritis (AIA) injury in rat kidney, focusing the angiotensin II/AT pathway. Male Wistar rats were allocated in to three groups: Control, AIA and AIA plus losartan.

Effects of adjuvant-induced arthritis on the ventral prostate of rats treated with angiotensin AT receptor blocker.

Aims: To analyze the prostatic compartments, extracellular matrix, microvascularization, transforming growth factor-beta (TGF-β) and angiotensin II receptors type 1 (AT) levels, and histopathology of the ventral prostate in a rat model for rheumatoid arthritis, and to evaluate the effect of angiotensin II AT receptor blocker (ARB) in the disease.

Main Methods: Fifteen male rats (90 days old) were divided into three groups (n = 5/group): control, adjuvant-induced arthritis without (AIA) or with AT receptor blocker (AIA + ARB). Animals were euthanized 60 days after immunization.