Publications by authors named "Eunsu Jeon"
Fecal microbiota transplantation (FMT) and probiotics therapies represent key clinical options, yet their complex effects on the host are not fully understood. We evaluated the comprehensive effects of FMT using diarrheal or normal feces, as well as probiotic therapies, on multiple anatomical sites in healthy cynomolgus macaques through colonoscopy and surgery. Our research revealed that FMT led to a partial microbiome transplantation without exhibiting the donor's fecal clinical characteristics.
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- The study focuses on the E6 and E7 proteins of HPV types 16 and 18, which are linked to cervical cancer, and explores the antitumor effects of a messenger RNA-HPV therapeutic vaccine (mHTV) designed with harmless versions of these proteins.
- Mice injected with mHTV showed strong immune responses and significantly slowed tumor growth, demonstrating effective treatment in both subcutaneous and orthotopic transplant models.
- Promising immune responses were also observed in rhesus monkeys, indicating potential for mHTV's clinical use in preventing and treating HPV-related cancers in humans.
Acute gastric dilatation (AGD) is one of the most prevalent and life-threatening diseases in nonhuman primates worldwide. However, the etiology of this syndrome has not been determined. Recently, sudden death occurred in a 7-year-old female cynomolgus monkey with a history of fecal microbiota transplantation using diarrheic stools.
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