Publications by authors named "Eunjae Yoo"
Article Synopsis
- * Overexpression of OTX2 in Group 3 MB cells increases growth, movement, and polarization, leading to decreased survival in animal models due to the development of brain and spinal cord metastases.
- * OTX2 activates the mTOR gene and its signaling pathway, enhancing cell migration, with a strong correlation found between OTX2 and mTOR expression in human MB samples, suggesting potential therapeutic targets by inhibiting mTORC2.
p53-binding protein 1 (53BP1) acts as an 'adaptor/mediator' for transducing DNA damage signals, especially following detection of DNA double-strand breaks. In an effort to broaden our understanding of the protein network surrounding 53BP1, we isolated possible 53BP1 binding partners by co-immunoprecipitation, and identified them via tandem mass spectrometric analysis. The 53BP1-associated proteins included RPA1 and RPA2, two components of the replication protein A (RPA) complex.
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