Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi from (Salicaceae).

Endophytes have been shown to be a source of novel drug prototypes. The genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present study endophytic fungi obtained from the fresh leaves of were grown in potato dextrose broth and rice to perform a secondary metabolite prospection study.

OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi of (Asteraceae).

Three endophytic fungi isolated from (Less.) G. Sancho (Asteraceae) were cultivated using the one strain many compounds (OSMAC) strategy to evaluate the production of griseofulvin derivatives.