Serially coupled columns enhance rapid separation and predictive interaction understanding of 93 fentanyl analogs.

Background: The simplicity of synthesis methods has facilitated the illegal manufacture of various fentanyl analogs, leading to numerous fatal overdoses worldwide, particularly in North America. Fentanyl analogs with similar structures are difficult to distinguish due to their fragmentation patterns, making separation using chromatography essential. Additionally, because fentanyl analogs are lethal even in trace amounts, they are easily smuggled, and commonly used fentanyl test strips often fail to detect them due to their low sensitivity.

Effects of the multi-channeled oral irrigation (MCOI) unit in preventing dental plaque formation and gingivitis: A randomized controlled trial.

Purpose: To evaluate the efficacy of COMORAL a new multi-channeled oral irrigation (MCOI) unit with pulsating water jet, in plaque score reduction and gingivitis.

Methods: This was a single-blinded clinical randomized controlled trial (NCT05031260). Forty-two healthy subjects between 18 to 35 years old were initially recruited, and the control group (n = 20) and the intervention group (n = 17) were randomly assigned.

A prospective multicenter clinical study on the efficiency of detachable ball- and spring-retained implant prosthesis.

Purpose: This prospective clinical study was conducted to evaluate the clinical usefulness of the freely detachable zirconia ball- and spring-retained implant prosthesis (BSRP) through a comparative analysis of screw- and cement-retained implant prosthesis (SCRP).

Materials And Methods: A multi-center, randomized, prospective clinical study evaluating the clinical usefulness of the detachable zirconia ball- and spring-retained implant prostheses was conducted. Sixty-four implant prostheses in 64 patients were examined.

Comparison of fit and trueness of zirconia crowns fabricated by different combinations of open CAD-CAM systems.

Purpose: This study aims to clinically compare the fitness and trueness of zirconia crowns fabricated by different combinations of open CAD-CAM systems.

Materials And Methods: Total of 40 patients were enrolled in this study, and 9 different zirconia crowns were prepared per patient. Each crown was made through the cross-application of 3 different design software (EZIS VR, 3Shape Dental System, Exocad) with 3 different processing devices (Aegis HM, Trione Z, Motion 2).

The oral microbiome of implant-abutment screw holes compared with the peri-implant sulcus and natural supragingival plaque in healthy individuals.

Purpose: An implant-supported prosthesis consists of an implant fixture, an abutment, an internal screw that connects the abutment to the implant fixture, and the upper prosthesis. Numerous studies have investigated the microorganisms present on the implant surface, surrounding tissues, and the subgingival microflora associated with peri-implantitis. However, there is limited information regarding the microbiome within the internal screw space.

Effect of Porcine- and Bovine-Derived Xenografts with Hydroxypropyl Methylcellulose for Bone Formation in Rabbit Calvaria Defects.

In this study, hydroxypropyl methylcellulose (HPMC) was mixed with particle-type xenografts, derived from two different species (bovine and porcine), to increase the manipulability of bone grafts and compare the bone regeneration ability. Four circular defects with a diameter of 6 mm were formed on each rabbit calvaria, and the defects were randomly divided into three groups: no treatment (control group), HPMC-mixed bovine xenograft (Bo-Hy group), and HPMC-mixed porcine xenograft (Po-Hy group). At eight weeks, micro-computed tomography (µCT) scanning and histomorphometric analyses were performed to evaluate new bone formation within the defects.

Hepatocellular Metabolic Abnormalities Induced by Long-Term Exposure to Novel Brominated Flame Retardant, Hexabromobenzene.

Novel brominated flame retardants (NBFRs) are widely used to avoid environmental accumulation concerns and because of the regulations imposed on classical BFRs. However, recent studies have not revealed the negative effects of NBFR accumulation and exposure on humans. We conducted a metabolomics study on hexabromobenzene (HBB), one of the NBFRs, to investigate its effect on hepatocytes.

Lipidomic Analysis of Cervicovaginal Fluid for Elucidating Prognostic Biomarkers and Relevant Phospholipid and Sphingolipid Pathways in Preterm Birth.

Cervicovaginal fluid (CVF) is an excellent specimen for monitoring preterm birth (PTB) as it characterizes cervical metabolites, the vaginal environment, and specific host immune responses. However, extensive lipid analysis of CVF to explain PTB has not been studied. In this study, we performed a systematic analysis combining high-throughput lipid analysis and omics to discover the unique metabolic properties of the cervix.

Comparison of retentive force and wear pattern of Locator® and ADD-TOC attachments combined with CAD-CAM milled bar.

Purpose: The purpose of this study was to investigate changes in retention and wear pattern of Locator® and ADD-TOC attachments on a digital milled bar by performing chewing simulation and repeated insertion/removal of prostheses in fully edentulous models.

Materials And Methods: Locator (Locator®; Zest Anchors Inc., Escondido, CA, USA) was selected as the control group and ADD-TOC (ADD-TOC; PNUAdd Co.

Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model.

In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones.

Retrospective Comparison of Postinsertion Maintenances Between Conventional and 3D Printed Complete Dentures Fabricated in a Predoctoral Clinic.

Purpose: A retrospective study to analyze the clinical performance of 3D printed complete dentures in edentulous patients compared with conventional complete dentures regarding postinsertion visits and patient reported outcomes.

Material And Methods: Electronic charts were reviewed to analyze 420 (maxilla 270, mandible 150) heat-polymerized conventional complete dentures (CCD) inserted between July 1, 2015 and June 30, 2016 and 217 (maxilla 130, mandible 86) 3D printed complete dentures (PCD) inserted between July 1, 2017 and June 30, 2018. Number of remakes, number of postinsertion adjustments, type and number of repairs, and patient reported complications were compared between two types of complete dentures.

Clinical evaluation of the fit of lithium disilicate crowns fabricated with three different CAD-CAM systems.

Statement Of Problem: The fit and performance of prostheses fabricated using various computer-aided design and computer-aided manufacturing (CAD-CAM) systems have been evaluated. However, most studies were conducted in vitro, and relatively few have addressed gingival parameters and prosthesis fit under clinical conditions.

Purpose: This clinical study aimed to compare the fit of lithium disilicate crowns produced using 3 CAD-CAM systems and evaluate clinical results up to 6 months after delivery.

Retrospective Clinical Study of a Freely Removable Implant-Supported Fixed Dental Prosthesis by a Microlocking System.

This retrospective clinical study was conducted to evaluate the clinical usefulness of a freely removable microlocking implant prosthesis (MLP) that was developed to overcome the problems with conventional implant prostheses. A total of 54 patients (male: 31, female: 23) and 100 implant prostheses were included. Patients were divided into three groups such as 6-12 months, 12-18 months, and 18-24 months according to the used period after implant prosthesis delivery, and the patients in each group were recalled for examinations of survival rate, marginal bone resorption, peri-implant soft tissue indices, and complications.

Evaluation of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Cross-Linked Collagen Membranes for Guided Bone Regeneration in Beagle Dogs.

The purpose of this study was to evaluate the bone regeneration efficacy of an 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked collagen membrane for guided bone regeneration (GBR). A non-cross-linked collagen membrane (Control group), and an EDC-cross-linked collagen membrane (Test group) were used in this study. In vitro, mechanical, and degradation testing and cell studies were performed.

Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement.

The purpose of this study was to investigate the effect of non-thermal atmospheric pressure plasma (NTP) treatment on the sandblasting of mechanical method and zirconia primer of chemical method used to increase the bond strength between zirconia and resin cement. In this study, Y-TZP was divided into 4 groups according to the surface treatment methods as follows: Zirconia primer (Pr), NTP + Zirconia primer (NTP + Pr), Sandblasting + Zirconia primer (Sb + Pr), Sandblasting + NTP + Zirconia primer (Sb + NTP + Pr). Then, two types of resin cement (G-CEM LinkAce and Rely X-U200) were used to measure the shear bond strength (SBS) and they were divided into non-thermal cycling group and thermal cycling group for aging effect.

Retrospective clinical evaluation of implant-assisted removable partial dentures combined with implant surveyed prostheses.

Statement Of Problem: Implant-assisted removable partial dentures (IARPDs) have been proposed as a treatment option for partially edentulous patients. However, evidence regarding the outcome of implant-assisted removable partial dentures with implant surveyed prostheses is limited.

Purpose: The purpose of this retrospective clinical study was to evaluate the clinical status and complications of IARPDs combined with implant surveyed prostheses in terms of clinical tissue condition, marginal bone resorption, and prosthetic complications.

Comparison of clinical fit of three-unit zirconia fixed prostheses fabricated using chairside and labside CAD/CAM systems.

The purpose of this study was to assess the clinical fit provided by EZIS system, the newly commercialized chairside CAD/CAM system. Prostheses were fabricated with the chairside CAD/CAM system (CS) and labside CAD/CAM system (LS) and marginal, axial, and occlusal fit of the prostheses were compared and analyzed by using replica technique. CS group presented significantly lower fit in all the three fits compared to LS group.

Cordless digital workflow for scanning implant-supported prostheses at the abutment level: A dental technique.

A custom abutment produced from a digital scan can be used to develop an implant-supported prosthesis with ideal contours. A scan body is used to obtain information about the location of the implant fixture, and the scan body has a special scan region that facilitates superimposition. This dental technique indirectly obtains the margin of the definitive prosthesis by designing the special scan region on a custom abutment and superimposing prescanned abutment data onto intraoral scanned data.

Comparison of Bone Regeneration between Porcine-Derived and Bovine-Derived Xenografts in Rat Calvarial Defects: A Non-Inferiority Study.

The present study aimed to compare the bone-regeneration capacity of porcine-derived xenografts to bovine-derived xenografts in the rat calvarial defect model. The observation of surface morphology and in vitro cell studies were conducted prior to the animal study. Defects with a diameter of 8 mm were created in calvaria of 20 rats.

Influence of Non-Thermal Atmospheric Pressure Plasma Treatment on Shear Bond Strength between Y-TZP and Self-Adhesive Resin Cement.

The purpose of this study was to evaluate the effect of non-thermal atmospheric pressure plasma (NTP) on shear bond strength (SBS) between yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) and self-adhesive resin cement. For this study, surface energy (SE) was calculated with cube-shaped Y-TZP specimens, and SBS was measured on disc-shaped Y-TZP specimens bonded with G-CEM LinkAce or RelyX U200 resin cylinder. The Y-TZP specimens were classified into four groups according to the surface treatment as follows: Control (no surface treatment), NTP, Sb (Sandblasting), and Sb + NTP.

Bone Regeneration Using a Three-Dimensional Hexahedron Channeled BCP Block Combined with Bone Morphogenic Protein-2 in Rat Calvarial Defects.

It is important to obtain sufficient bone mass before implant placement on alveolar bone, and synthetic bone such as biphasic calcium phosphate (BCP) has been studied to secure this. This study used a BCP block bone with a specific structure of the three-dimensional (3D) hexahedron channel and coating with recombinant human bone morphogenetic protein-2 (rhBMP-2) impregnated carboxymethyl cellulose (CMC) was used to examine the enhancement of bone regeneration of this biomaterial in rat calvarial defect. After the preparation of critical-size calvarial defects in fifteen rats, defects were divided into three groups and were implanted with the assigned specimen (n = 5): Boneplant (untreated 3D hexahedron channeled BCP block), Boneplant/CMC (3D hexahedron channeled BCP block coated with CMC), and Boneplant/CMC/BMP (3D hexahedron channeled BCP block coated with CMC containing rhBMP-2).

Comparison of the Trueness of Lithium Disilicate Crowns Fabricated From All-in-One and Combination CAD/CAM Systems.

Purpose: To examine and compare the trueness between a computer-aided design (CAD) file and the final milled prosthesis.

Materials And Methods: For each included patient (n = 30), two lithium disilicate crowns were produced (n = 60) using two different CAD/computer-assisted manufacture (CAD/CAM) systems (all-in-one type and combination type). To compare the trueness, the scanned internal surfaces of the fabricated prostheses were compared to the design files in CAD using 3D analysis software (Geomagic Control X, 3D Systems).

Wear Characteristics of Dental Ceramic CAD/CAM Materials Opposing Various Dental Composite Resins.

The aim of this study was to evaluate the wear properties of opposed dental ceramic restorative CAD/CAM materials and several posterior direct restorative composite resins. Three kinds of dental ceramics CAD/CAM materials (monolithic zirconia, lithium disilicate, leucite) and four dental composite resins-that is, MI Gracefil, Gradia Direct P, Estelite Σ Quick, and Filtek Supreme Ultra-were used in this study. For each of the 12 groups (three ceramics × four composite resins), five each of a canine-shaped ceramic specimen and a cuboidal shape opposing composite resin were prepared.

Implant-supported fixed dental prosthesis with a microlocking implant prosthetic system: A clinical report.

A microlocking implant prosthetic system has recently been developed to address the limitations of conventional screw- and cement-retained implant-supported fixed dental prostheses. This prosthesis system consists of a precision-machined abutment and an attachment that includes zirconia balls and a nickel-titanium spring, thus providing retrievability and constant retention of the prosthesis. In addition, screw-related complications are avoided because there is no retention screw.