Cosmetic patent and female invention.

Majority customers of cosmetics are female. Would this imply a high proportion of inventors of cosmetics technology is female? Would the inventor's gender be related to the characteristics and quality of corresponding patent? This study tries to identify manifestation of gender equity in cosmetics technology in terms of patent application and grant, technical characteristics, and its performance. We apply topic modeling, zero-inflated Poisson regression, and survival analysis to patents related to cosmetics that were applied to the United States Patent and Trademark Office from 1970 to 2016.

Optimized quantification of fatty acids in complex media using advanced analytical techniques.

Rationale: Various medium formulations contain essential fatty acids at concentrations ranging from 10 to 100 mg/L. Accurate and precise lipid measurement in media is crucial for monitoring media quality and conducting studies on lipids in the context of cell culture. This study employed two-dimensional gas chromatography (GC × GC) analyses to offer enhanced resolution, sensitivity, and separation performance compared to GC.

In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.

EWS RNA binding protein 1 (EWSR1) is a multifunctional protein whose epigenetic signatures contribute to the pathogenesis of various human diseases, such as neurodegenerative disorders, skin development, and tumorigenic processes. However, the specific cellular functions and physiological characteristics of EWSR1 remain unclear. In this study, we used quantitative mass spectrometry-based proteomics with tandem mass tag labeling to investigate the global proteome changes in brain tissue in Ewsr1 knockout and wild-type mice.

Digital Therapeutics Product Repositioning via Multiplex Link Prediction Based on Genomic, Chemical, and Technological Information.

Digital therapeutics (DTx) companies are making efforts to expand their consumer base in the growing market. To this end, many of them reposition their existing products to identify new target diseases. In this study, we provide a link prediction framework for DTx product repositioning on the basis of a multiplex disorder network by integrating multiple data sources, such as associated genes between disorders, shared drugs, and patents of treatment protocols.

Oil spill fingerprint of low sulfur fuel oil in South Korea.

A low sulfur fuel oil (LSFO) spill accident occurred in South Korea on December 17, 2019, before the introduction of the International Maritime Organization (IMO) sulfur limit. In this study, chromatograms, percentage weathering plots (PW-plots), and diagnostic ratios (DRs) of LSFOs collected in different areas during in the early spillage were compared for oil spill fingerprint. The source oil was conformed as LSFO according to physical properties and spill oils, like the source oil, show high n-alkanes and low benzo[b]naphto[1,2-d]thiophene (BNT) distribution.

Multiplex PCR analysis of virulence genes and their influence on antibiotic resistance in spp. isolated from broiler chicken.

spp. are opportunistic pathogens that cause lameness in broiler chickens, resulting in serious economic losses worldwide. Virulence of spp.