The alternative bile acid pathway can predict food allergy persistence in early childhood.

Background: Mechanisms underlying persistent food allergy (FA) are not well elucidated. The intestinal mucosa is the primary exposure route of food allergens. However, no study has examined intestinal metabolites associated with FA persistence.

Combined effect of hygienic and polygenic risk scores in children with allergic rhinitis.

Background: Although the development of allergic rhinitis (AR) is associated with multiple genetic and hygienic environmental factors, previous studies have focused mostly on the effect of a single factor on the development of AR.

Objective: This study aimed to investigate the combined effect of multiple genetic and hygienic environmental risk factors on AR development in school children.

Methods: We conducted a cross-sectional study, comprising 1,797 children aged 9-12 years.

Regulation of the ald gene encoding alanine dehydrogenase by AldR in Mycobacterium smegmatis.

The regulatory gene aldR was identified 95 bp upstream of the ald gene encoding L-alanine dehydrogenase in Mycobacterium smegmatis. The AldR protein shows sequence similarity to the regulatory proteins of the Lrp/AsnC family. Using an aldR deletion mutant, we demonstrated that AldR serves as both activator and repressor for the regulation of ald gene expression, depending on the presence or absence of L-alanine.