Publications by authors named "Eun-Ju Son"
Article Synopsis
- The text discusses the ongoing debate and research around low sexual desire in women partnered with men, highlighting a lack of understanding about how women perceive the causes of their low desire.
- A study involving 130 women identified five categories for the causes of low desire: psychological/individual, relational, biological, sociocultural, and sexual orientation/identity/status, with many women citing multiple factors.
- The research found that while most women felt negative emotions about their low desire, their feelings were influenced by their specific attributions, indicating the need for a deeper examination of these attributions to understand women's emotional experiences better.
Article Synopsis
- Fulvic acids (FAs) are valued in cosmetics and agriculture for their beneficial effects but are limited in extraction sources, prompting a need for sustainable alternatives.
- Researchers have successfully used ionic liquids (ILs) to extract fulvic-like substances (FLSs) from wood sawdust, which share similar molecular properties with commercial FAs.
- The extracted FLSs demonstrated enhanced biological activities, including better antioxidant effects and positive impacts on plant growth, and showed promise in promoting hair-related protein expression in human cells and in mice, indicating their potential as a renewable source of functional compounds.
Purpose: To investigate whether preoperative ultrasonographic (US) features of the index cancer and metastatic lymph nodes (LNs) are associated with level II LN metastasis in N1b papillary rmfthyroid carcinoma (PTC) patients.
Materials And Methods: We enrolled 517 patients (mean age, 42 [range, 6-80] years) who underwent total thyroidectomy and lateral compartment LN dissection between January 2009 and December 2015. We reviewed the clinicopathologic and US features of the index cancer and metastatic LNs in the lateral neck.
Article Synopsis
- The study examines how feminist views shape men's perspectives on sexual desire, especially among men who identify as feminist in heterosexual relationships.* -
- Researchers interviewed 30 feminist-identified heterosexual men to understand their experiences with sexual desire in the context of evolving gender norms.* -
- Results showed that most men felt no conflict between their feminist beliefs and sexual desires, often utilizing communication with partners to navigate any ambivalence, highlighting the positive effects of feminism on their sexuality and relationships.*
Article Synopsis
- The study investigated the clinical importance of tumor stiffness in breast cancer and its relationship with tumor-infiltrating lymphocyte (TIL) levels using shear-wave elastography (SWE), examining 803 patients from January 2016 to August 2020.
- Results showed that higher tumor stiffness was linked to larger tumor size and more advanced disease stages, but negatively associated with TIL levels, especially in hormone receptor-positive and HER2-negative subtypes.
- The findings suggest that tumor stiffness has different clinical meanings depending on the breast cancer type, with increased stiffness indicating more aggressive behavior primarily in hormone receptor-positive and HER2-negative tumors, while high TIL levels are associated with lower stiffness across all subtypes.
Article Synopsis
- The study aimed to create and assess AI algorithms for ultrasound microflow imaging to improve breast cancer diagnosis.
- A dataset of 516 breast lesions was analyzed, with AI algorithms showing a higher accuracy (AUROC of 0.955-0.966) compared to traditional B-mode ultrasound (AUROC of 0.842).
- Combining AI with B-mode ultrasound significantly enhanced diagnostic performance and reduced false positives from 87% to 13% for certain lesion categories.
Article Synopsis
- Shear-wave elastography (SWE) is a useful method for identifying malignant breast lesions and lymph node metastasis in breast cancer patients, but its relationship with chemotherapy response is still unclear.
- In a study of 830 patients undergoing neoadjuvant chemotherapy, those with lower baseline stiffness values (E-mean and E-max) showed significantly higher rates of pathological complete response (pCR) to treatment.
- The findings suggest that low elasticity values from SWE could be independent predictors of treatment success and are associated with high tumor-infiltrating lymphocytes (TILs), particularly in hormone receptor-positive HER2-negative and triple-negative breast cancers.
Article Synopsis
- - The study aims to create and validate nomograms that incorporate shear-wave elastography (SWE) data with clinical features to predict the Oncotype DX recurrence score (RS) for breast cancer patients undergoing systemic therapy.
- - Researchers analyzed data from 381 women with breast cancer, using a portion of the patients for developing the nomograms and the rest for independent validation; results showed that SWE indices are significantly related to the predicted RS values.
- - The nomograms demonstrated effective predictive capabilities, with area under the receiver operating characteristic curve (AUROC) values indicating strong performance for both lower (≥16) and higher (≥26) RS thresholds, suggesting they can assist in therapy decision-making.
Article Synopsis
- This study investigates how certain fungi and microbial consortia break down lignin from plants, potentially leading to unique biological activities that could stimulate plant growth.
- Through microbial metabolism, lignin-derived products were found to contain beneficial organic compounds, showing increased properties like phenols and antioxidant capacity over time.
- The research confirmed that specific microbes, particularly white-rot fungi, effectively transform lignin, resulting in substances that promote plant root elongation, highlighting the role of microbial activity in enhancing soil quality.
This study aimed to investigate whether preoperative ultrasonographic (US) features of metastatic lymph nodes (LNs) are associated with tumor recurrence in patients with N1b papillary thyroid carcinoma (PTC). We enrolled 692 patients (mean age, 41.9 years; range, 6-80 years) who underwent total thyroidectomy and lateral compartment LN dissection between January 2009 and December 2015 and were followed-up for 12 months or longer.
View Article and Find Full Text PDFThis study aimed to assess the diagnostic performance of deep convolutional neural networks (DCNNs) in classifying breast microcalcification in screening mammograms. To this end, 1579 mammographic images were collected retrospectively from patients exhibiting suspicious microcalcification in screening mammograms between July 2007 and December 2019. Five pre-trained DCNN models and an ensemble model were used to classify the microcalcifications as either malignant or benign.
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- A study investigated the effectiveness of abbreviated breast MRI for patients with suspicious microcalcifications detected on screening mammograms, including 80 patients undergoing the procedure before biopsy from August 2017 to September 2020.
- Results showed that abbreviated MRI significantly improved the positive predictive value (PPV) from 33.8% to 75.8%, indicating better accuracy in identifying true cases of malignancy.
- The use of abbreviated MRI also led to an 85% reduction in unnecessary biopsies for benign lesions, confirming its additional diagnostic value without missing invasive cancers.
Article Synopsis
- Objective: The study aimed to evaluate the effectiveness of texture analysis in MRI for predicting breast cancer recurrence in patients receiving neoadjuvant chemotherapy.
- Methods: It analyzed data from 130 women who underwent surgery after chemotherapy, using a random forest model and comparing the predictive accuracy of texture analysis with traditional MRI features.
- Results: This analysis found that texture assessment from MRI provided better predictive accuracy (AUC of 0.94) for recurrence compared to standard MRI features (AUC of 0.83), suggesting that it could be an important tool for prognosis in breast cancer treatment.
Article Synopsis
- This study aimed to assess how well a deep convolutional neural network (CNN) compares to expert radiologists in identifying thyroid nodules using ultrasonography (US).
- The research utilized a large dataset of 15,375 ultrasound images collected from multiple centers to train and test various CNN models for distinguishing between malignant and benign nodules.
- Results indicated that the CNN performed similarly or better than radiologists in detecting malignant nodules, achieving higher diagnostic accuracy in some internal tests, while showing comparable performance in external tests.
Article Synopsis
- The study compares mammographic density assessment using automated volumetric measurements recalibrated to the BI-RADS 5th edition against traditional visual assessments by radiologists.
- Analysis involved 4,000 mammograms, revealing that volumetric measurements indicated higher dense categories and a lower proportion of fatty tissue in patients with breast cancer compared to those without.
- The findings indicate that while the recalibrated volumetric measurements differ from visual assessments, they still show some correlation, suggesting that the recalibration has not fully aligned with visual judgment.
Purpose: Insertion of radiopaque markers is helpful for tumor localization in patients receiving neoadjuvant chemotherapy (NAC) followed by breast-conserving surgery (BCS). The aim of this retrospective study was to investigate the pathologic margin status in patients with single or double marker insertion.
Methods: We reviewed the records of 130 patients with marker insertion prior to NAC followed by BCS from January 2016 to September 2019.
Article Synopsis
- A new scoring system was developed to evaluate the risk of breast cancer in patients with microcalcifications using the 5th edition of the Breast Imaging Reporting and Data System (BI-RADS).
- The study reviewed 194 lesions, found that 36% were malignant after surgery, and established significant differences in positive predictive values (PPV) for different BI-RADS categories.
- The scoring system demonstrated good accuracy with an AUROC of 0.874, helping to effectively stratify malignancy risk, and was further validated with another dataset showing similar results.
Article Synopsis
- - The study aimed to evaluate if ultrasound and MRI can predict the response of axillary lymph nodes in breast cancer patients undergoing neoadjuvant chemotherapy (NAC).
- - Researchers analyzed imaging data from 131 patients with positive axillary lymph nodes, finding significant correlations between imaging features, tumor size, and lymph node status post-surgery.
- - The results indicated that monitoring both lymph node morphology and tumor size using ultrasound and MRI is effective in predicting axillary response to NAC, with ultrasound showing the best diagnostic performance.
Background Previous studies have suggested that texture analysis is a promising tool in the diagnosis, characterization, and assessment of treatment response in various cancer types. Therefore, application of texture analysis may be helpful for early prediction of pathologic response in breast cancer. Purpose To investigate whether texture analysis of features from MRI is associated with pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer.
View Article and Find Full Text PDFPurpose: To identify and compare diagnostic performance of radiomic features between grayscale ultrasound (US) and shear-wave elastography (SWE) in breast masses.
Materials And Methods: We retrospectively collected 328 pathologically confirmed breast masses in 296 women who underwent grayscale US and SWE before biopsy or surgery. A representative SWE image of the mass displayed with a grayscale image in split-screen mode was selected.
Article Synopsis
- - A nomogram was created to predict lymph node (LN) metastasis during breast cancer surgery using shear-wave elastography (SWE) and nodal size from 228 axillary LNs in a study of 55 patients, and validated in an independent cohort of 80 patients with 217 sentinel LNs.
- - The nomogram displayed strong predictive ability with an AUC of 0.856 in the development group and 0.791 in the validation group; metastatic LNs exhibited significantly higher stiffness and elasticity ratios compared to non-metastatic LNs, though their sizes were not significantly different.
- - This tool could help streamline procedures by decreasing the need for intraoperative frozen sections, ultimately reducing surgical time and
Polo-like kinase 1 (Plk1) regulates cell cycle and cell proliferation, and is currently considered a potential biomarker in clinical trials for many cancers. A characteristic feature of Plks is their C-terminal polo-box domain (PBD). Pro-Leu-His-Ser-pThr (PLHS[pT])-the phosphopeptide inhibitor of the PBD of Plk1-induces apoptosis in cancer cells.
View Article and Find Full Text PDFConsidering the emergence of bacterial resistance and low proteolytic stability of antimicrobial peptides (AMPs), herein we developed a series of ultra-short triazine based amphipathic polymers (TZP) that are connected with ethylene diamine linkers instead of protease sensitive amide bond. The most potent oligomers, TZP3 and TZP5 not only displayed potent antibacterial action on various drug-resistant pathogens but also exhibited a strong synergic antibacterial activity in combination with chloramphenicol against multidrug-resistant Pseudomonas aeruginosa (MDRPA). Since most of atopic dermatitis (AD) infections are caused by bacterial colonization, we evaluated the potency of TZP3 and TZP5 on AD in vitro and in vivo.
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- The study examined the effectiveness of breast MRI in assessing tumor size and positive margins in patients who had breast-conserving surgery (BCS) for different breast cancer subtypes.
- It found that MRI correlated better with actual tumor size compared to ultrasound, especially for triple-negative breast cancer (TNBC), while the agreement was lower for HER2-positive tumors.
- Additionally, HER2-positive patients had a higher rate of positive margins compared to other subtypes, suggesting that imaging may not align well with pathology in this group.
Article Synopsis
- - Glycogen-rich clear cell carcinoma (GRCC) is a rare and aggressive breast cancer that hasn't been extensively studied in terms of imaging characteristics.
- - In this report, imaging findings from three GRCC cases were analyzed, revealing that mammography typically shows irregular or oval-shaped masses, while ultrasound presents a mix of cystic and solid areas.
- - On MRI, GRCC appears as a high signal intensity mass on T-weighted images, with enhancement around the edges after contrast, which may help differentiate it from other breast tumors.