Publications by authors named "Eun-Hye Jeon"
A study on the formative usability testing for modular powered wheelchair.
Disabil Rehabil Assist Technol
February 2025
The increasing prevalence of mobility impairments underscores the urgent need for accessible and affordable mobility aids. To overcome the mobility limitations of people with disabilities, there is an increasing need for the development of lightweight and portable powered wheelchairs that can be easily loaded. This study aimed to perform an early health technology assessment and a formative usability evaluation on a modular (detachable) powered wheelchair.
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- Identifying genes related to stemness is key for treating metastatic carcinoma effectively.
- The study found that silencing ribosomal protein L9 (RPL9) reduces growth and invasive capabilities in colorectal cancer (CRC) cells by disrupting ID-1 signaling, which is important for cancer cell survival.
- Targeting RPL9 also diminishes the stem cell-like properties in CRC stem cells, implying it could be a promising therapeutic target to improve treatment outcomes and prevent cancer recurrence.
Although expression of ribosomal protein L27 (RPL27) is upregulated in clinical colorectal cancer (CRC) tissue, to the best of our knowledge, the oncogenic role of RPL27 has not yet been defined. The present study aimed to investigate whether targeting RPL27 could alter CRC progression and determine whether RPL27 gains an extra‑ribosomal function during CRC development. Human CRC cell lines HCT116 and HT29 were transfected with RPL27‑specific small interfering RNA and proliferation was assessed and using proliferation assays, fluorescence‑activated cell sorting (FACS) and a xenograft mouse model.
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- Ribosomal protein L17 (RPL17) is found to be up-regulated in colorectal cancer (CRC), signaling a potential role in cancer progression that has not been previously studied.
- The research utilized RPL17-specific siRNAs to silence its expression in CRC cells, leading to decreased cell growth, reduced colony formation, and suppressed tumor formation in mouse models.
- Molecular analyses revealed that RPL17 silencing down-regulated key proteins associated with cell proliferation and stemness, suggesting it plays an oncogenic role in CRC by enhancing tumor cell survival and invasive capabilities.
Background: This study was conducted to analyze clinical factors that can affect pregnancy rates in normal responders undergoing the freeze-all policy in in vitro fertilization.
Methods: We evaluated 153 embryo transfer cycles in 89 infertile women with normal response to controlled ovarian stimulation (COS). After COS, all embryos were cultured to the blastocyst stage, and good quality blastocysts were vitrified for elective frozen-thawed embryo transfer (FET).