Antimicrobial activities of leptospermone isolated from seeds and structure-activity relationships of its derivatives against foodborne bacteria.

This study was carried out to determine the antimicrobial activities of leptospermone isolated from and its derivatives against six foodborne bacteria (, , , , and ), with a view to developing safer antimicrobial agents. The essential oil of seeds possessed potent antimicrobial activity against six bacterial strains. The antimicrobial compound of was isolated by chromatographic analyses and identified as leptospermone.

Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts.

Cordycepin (3-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the present study, we investigated the inhibitory effects of cordycepin on matrix metalloproteinase-1 (MMP-1) and -3 expressions of the human dermal fibroblast cells.