Bacterial extracellular vesicles affect endocrine therapy in MCF7 cells.

Background: : The microbiome is important in the development and progression of breast cancer. This study investigated the effects of microbiome derived from Klebsiella on endocrine therapy of breast cancer using MCF7 cells. The bacterial extracellular vesicles (EVs) that affect endocrine therapy were established through experiments focused on tamoxifen efficacy.

Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines.

Purpose: Papillary thyroid cancer (PTC) has a high incidence of BRAF mutation. The purpose of this study was to evaluate the potential relationship between thyroiditis and BRAF mutation status in patients with PTC. We investigated how a selective inhibitor of BRAF PLX4032 affects the proliferation and inflammatory cytokine levels of thyroid cancer.

Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells.

Background/aim: MEK-ERK pathway plays major roles in the progression of thyroid cancer, while the use of MEK-ERK inhibitors has been limited by its toxicity. We investigated the effect of sodium selenite as an adjunct for MEK-ERK inhibitors to avoid the toxicity of ERK inhibitors.

Materials And Methods: TPC1, 8505C and HTori-3 cells were treated with U0126 (MEK-ERK inhibitor) and cell viability was counted in the Neubauer chamber.