Publications by authors named "Eun Joo Lee"
Article Synopsis
- - The study evaluated the safety and effectiveness of Fybro, a generic antifibrotic medication for idiopathic pulmonary fibrosis (IPF), with a focus on its real-world performance over 6-12 months.
- - Out of 359 patients enrolled, a large majority (71.9%) experienced adverse events, with decreased appetite being the most common issue; however, lung function decline rates did not vary significantly across different dosages of Fybro.
- - The findings suggest that using higher-dose Fybro tablets can enhance patient adherence to medication regimens, proposing that fewer pills daily may lead to better treatment compliance.
Article Synopsis
- Replicative senescence in mesenchymal stem cells (MSCs) reduces their ability to grow and work as effective therapies, creating challenges for cell therapy.
- The study investigates the role of glutaminase-1 (GLS1) in MSC senescence, showing that inhibiting GLS1 can help remove senescent cells and improve MSC functionality.
- Findings reveal that GLS1 inhibition in Wharton's jelly-derived MSCs enhances their proliferation, muscle formation, and overall therapeutic potential, suggesting GLS1 as a target for improving MSC-based treatments in muscle diseases like Duchenne muscular dystrophy.
Article Synopsis
- Wilson disease (WD) is a rare genetic disorder that disrupts copper metabolism, requiring lifelong medication to prevent severe complications like liver failure; the study evaluated the efficacy and safety of three treatments: D-penicillamine (DPA), trientine, and zinc in children.
- The analysis included 90 patients, excluding those who had liver transplants, and revealed that treatment ineffectiveness was most common with trientine, followed by zinc and DPA.
- The findings indicated that while all three treatments are effective for pediatric WD, DPA and zinc have more adverse effects compared to trientine, suggesting that trientine may be the safer choice.
Article Synopsis
- Maintaining transparent surfaces on protective covers with transparent heaters is crucial for safety in self-driving cars, especially in extreme weather conditions.
- Achieving both high light transmission and low electrical resistance in these heaters is a significant challenge, but metamaterial design offers a solution.
- The developed heaters are ultra-thin, microwave-transparent, and can heat up to 180°C quickly, effectively removing thin ice layers in freezing temperatures.
Article Synopsis
- Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is involved in various biological processes, but its specific role in skeletal muscle development and maintenance had not been studied before this research.
- The study used skeletal muscle-specific hnRNPU knockout mice to discover that the absence of hnRNPU led to an increase in immune cell infiltration and subsequent muscle atrophy, indicating its importance in muscle health.
- Further experiments showed that inhibiting immune cell proliferation with salirasib prevented muscle atrophy, highlighting the connection between hnRNPU loss, inflammation, and muscle deterioration through NF-κB signaling activation.
Article Synopsis
- Childhood obesity is linked to a rising prevalence of nonalcoholic fatty liver disease (NAFLD) in kids and teens, yet systematic studies on this issue are scarce.
- A comprehensive search of multiple databases yielded 62 relevant studies for analysis, revealing that NAFLD affects 13% of the general pediatric population and 47% of obese kids.
- The study found significant gender differences in prevalence, with higher rates in males than females for both general and obese populations, highlighting the urgent need for more epidemiological research on NAFLD in pediatrics.
Article Synopsis
- The gut mycobiome is important for human gut health, but research on its functions is not as extensive as for gut bacteria.
- This study compares different DNA extraction methods for analyzing the mycobiome, using two commercial kits and a manual method, as well as different bead-beating machines.
- Results indicate that the DNeasy PowerSoil Pro Kit combined with the Mini-Beadbeater-16 is the most effective method for extracting DNA from human fecal samples, leading to a proposed standard operating procedure for future studies.
Article Synopsis
- The text references a correction made to an article found on page 280 of volume 51, which has a specific PubMed identifier (PMID: 34215707).
- It implies that there was an error or misleading information in the original article that needed clarification.
- The focus is on ensuring accurate information is available in academic publications.
Article Synopsis
- The study aimed to investigate the link between limaprost use and bleeding risks using a large health database from South Korea.
- Researchers analyzed data from over 72,000 patients and found that bleeding incidents were 1.5 times more likely during limaprost exposure, especially during the first week of use.
- Higher bleeding risks were noted when limaprost was taken alongside antithrombotics or in larger doses, indicating that careful consideration is needed before starting the medication, particularly in combination with other drugs.
Article Synopsis
- - This study explored the link between types of surgery for gastric cancer (gastrectomy vs. endoscopic resection) and the occurrence of tuberculosis post-surgery, using data from over 90,000 patients in South Korea from 2013 to 2019.
- - Results showed that patients who underwent gastrectomy had a significantly higher incidence of tuberculosis compared to matched individuals who did not have the surgery, while endoscopic resection showed no significant difference in tuberculosis occurrence.
- - Importantly, tuberculosis incidence rose notably within the first year after patients had endoscopic resection, indicating a need for monitoring in this early post-surgical period.
Lymphangioleiomyomatosis and mTOR inhibitors in real world-a narrative review.
J Thorac Dis
November 2023
Article Synopsis
- - Lymphangioleiomyomatosis (LAM) is a rare and challenging disease primarily affecting the lungs, with both pulmonary and extra-pulmonary symptoms.
- - The introduction of mTOR inhibitors has improved management and control of LAM, although issues such as treatment duration and other unresolved challenges remain.
- - This study reviewed various aspects of LAM, including its causes, symptoms, lab findings, management strategies, and the effectiveness of mTOR inhibitors alongside emerging therapies.
Article Synopsis
- Testicular germ cell tumors (TGCTs) are common in young males and often respond well to cisplatin chemotherapy, but some patients don’t respond and experience negative side effects.
- Research explored the effects of KPT6566, a selective inhibitor of the protein Pin1, on TGCT cell growth and viability, revealing it significantly reduced cell proliferation and induced cell death.
- KPT6566 also demonstrated antitumor effects in a mouse model, suggesting that targeting Pin1 may offer a new therapeutic strategy for treatment-resistant TGCTs.
Article Synopsis
- - The process of bone regeneration involves several factors, including inflammation, tissue interactions, and progenitor cells, with complications in trauma cases often leading to delayed healing that may require bone grafting, which has drawbacks like donor site morbidity and material availability.
- - Adipose-derived stem cells (ASCs) have shown promise in enhancing bone regeneration; findings indicate that a specific treatment group (C/S) exhibited faster and more effective bone healing compared to others, as measured by radiological assessments and Micro-CT imaging.
- - The study highlights the potential of ADMSCs for clinical applications in treating bone diseases, showing that while newly formed bone differed slightly in density from normal tissue, the overall findings support their use in regenerative medicine and early-stage
Article Synopsis
- * In a rat model of BPH induced by testosterone, HLT-101 was administered at different doses and showed a reduction in oxidative stress and inflammation-related gene expression.
- * The results indicated that HLT-101 could decrease harmful free radical production and inflammatory activation, making it a potential therapeutic option for BPH by targeting key signaling pathways.
Article Synopsis
- Cellular senescence leads to a halt in cell growth, affecting mesenchymal stem cells (MSCs) by reducing their ability to proliferate and differentiate, making aged MSCs unsuitable for therapeutic use.
- Researchers have identified nervonic acid (NA) from a fecal metabolites library as a promising candidate that can regulate this senescence in MSCs.
- NA was found to decrease indicators of senescence, promote stem cell qualities, and improve cell proliferation, suggesting its potential as a treatment for managing cellular aging.
Article Synopsis
- The study explores the social stigma and discrimination faced by COVID-19 survivors in South Korea during the first two years of the pandemic.
- Out of 52 participants, 45 reported experiencing stigma in their personal relationships, workplaces, and children's schools, with sexual minorities facing heightened discrimination.
- The findings highlight how survivors felt they caused trouble and raised fears of virus transmission, emphasizing the cultural contexts that shape stigma in East Asia.
New prognostic scoring system for mortality in idiopathic pulmonary fibrosis by modifying the gender, age, and physiology model with desaturation during the six-minute walk test.
Jae Ha Lee Ji Hoon Jang Hang-Jea Jang Song Yee Kim Man Pyo Chung Hong Lyeol Lee Jongmin Lee Hyun-Kyung Lee Hyun Lee Eun-Joo Lee Won-Yeon Lee
Front Med (Lausanne)
January 2023
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD) with variable and heterogeneous clinical course. The GAP (gender, age, and physiology) model had been used to predict mortality in patients with IPF, but does not contain exercise capacity. Therefore, our aim in this study was to develop new prognostic scoring system in the Korea IPF Cohort (KICO) registry.
View Article and Find Full Text PDFOptimal Nozzle Position and Patient's Posture to Enhance Drug Delivery into the Peritoneum during Rotational Intraperitoneal Pressurized Aerosol Chemotherapy in a Swine Model.
Dong Won Hwang Eun Ji Lee Joo Yeon Chung Eun Joo Lee Dayoung Kim Seungmee Lee Sung Jong Lee San-Hui Lee
J Pers Med
October 2022
Article Synopsis
- Research on RIPAC shows that patient posture greatly influences the distribution of chemotherapy agents, with the Trendelenburg position yielding better results for aerosol spread in the abdomen.* -
- The study involved testing on nine pigs using a specific aerosol delivery method (DreamPen) and highlighted that depth and nozzle positioning affect penetration depth and distribution.* -
- Results indicate that optimal distribution and penetration for anti-cancer agents can be achieved at a medium depth (around 4 cm) with the Trendelenburg position, suggesting important considerations for treatment effectiveness.*
Precise regulation of the cell cycle of embryonic stem cells (ESCs) is critical for their self-maintenance and differentiation. The cell cycle of ESCs differs from that of somatic cells and is different depending on the cell culture conditions. However, the cell cycle regulation in ESCs via epigenetic mechanisms remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- - Myxoid pleomorphic liposarcoma combines features of both pleomorphic and myxoid liposarcomas and was identified in a 5-year-old male African pygmy hedgehog, consisting of about 60% myxoid substance and 30% pleomorphic neoplastic cells.
- - Despite the presence of extrapulmonary metastasis, the hedgehog showed a good prognosis over 6 months, indicating potential similarities in outcomes with human myxoid liposarcoma cases.
- - Analyzing the proportions of myxoid and pleomorphic areas may provide insights into prognosis and metastasis, suggesting a method for tailoring treatment plans for this rare form of cancer, which also has implications for
Article Synopsis
- - Two zinc complexes, [Zn(DAT)Cl] and [Zn(DAT)(NO)], were synthesized using a mechanochemical method that resulted in over 99% yield, differing from traditional solution methods.
- - Crystal structures revealed complex () has a monoclinic arrangement while complex () is triclinic, both featuring a unique DAT-bridged dimer and slightly distorted tetrahedral geometry for zinc centers.
- - Both complexes showed blue emissions at room temperature and demonstrated promising anticancer activity against HeLa, NCCIT, and MCF-7 cancer cell lines.
Article Synopsis
- Self-sampling for COVID-19 detection can help those unable to visit hospitals and reduce the workload on healthcare workers.
- A study compared self-collected nasal/oral swabs and saliva samples from 50 COVID-19 patients and 50 healthy individuals, finding acceptable diagnostic performance.
- The self-collected specimens showed high agreement with healthcare worker-collected samples, especially in cases with high viral loads, indicating it could be a valuable tool for early COVID-19 diagnosis.
Article Synopsis
- - Blood vessels have a complex 3D structure that's difficult to analyze with traditional methods, which often damage their topological arrangement.
- - This study used tissue optical clearing techniques combined with light-sheet and confocal microscopy to create high-resolution 3D images of rat brain vasculature after inducing a temporary stroke.
- - Findings indicated that the ischemic area showed reduced blood vessel diameter and density, along with notable neuronal loss and increased astrocyte activity, highlighting the effectiveness of these methods for studying cerebrovascular and neuronal changes in brain disorders.